Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

The MUSASHI (MSI) family of RNA binding proteins (MSI1 and MSI2) contribute to a wide spectrum of cancers including acute myeloid leukemia. We find that the small molecule Ro 08–2750 (Ro) binds directly and selectively to MSI2 and competes for its RNA binding in biochemical assays. Ro treatment in m...

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Detalles Bibliográficos
Autores principales: Minuesa, Gerard, Albanese, Steven K., Xie, Wei, Kazansky, Yaniv, Worroll, Daniel, Chow, Arthur, Schurer, Alexandra, Park, Sun-Mi, Rotsides, Christina Z., Taggart, James, Rizzi, Andrea, Naden, Levi N., Chou, Timothy, Gourkanti, Saroj, Cappel, Daniel, Passarelli, Maria C., Fairchild, Lauren, Adura, Carolina, Glickman, J. Fraser, Schulman, Jessica, Famulare, Christopher, Patel, Minal, Eibl, Joseph K., Ross, Gregory M., Bhattacharya, Shibani, Tan, Derek S., Leslie, Christina S., Beuming, Thijs, Patel, Dinshaw J., Goldgur, Yehuda, Chodera, John D., Kharas, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584500/
https://www.ncbi.nlm.nih.gov/pubmed/31217428
http://dx.doi.org/10.1038/s41467-019-10523-3

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