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Analysis and remedy of negativity problem in hybrid stochastic simulation algorithm and its application

BACKGROUND: The hybrid stochastic simulation algorithm, proposed by Haseltine and Rawlings (HR), is a combination of differential equations for traditional deterministic models and Gillespie’s algorithm (SSA) for stochastic models. The HR hybrid method can significantly improve the efficiency of sto...

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Detalles Bibliográficos
Autores principales: Chen, Minghan, Cao, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584509/
https://www.ncbi.nlm.nih.gov/pubmed/31216983
http://dx.doi.org/10.1186/s12859-019-2836-z