Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain

Neuropathic pain is a major incurable clinical problem resulting from peripheral nerve trauma or disease. A central mechanism is the reduced expression of the potassium chloride cotransporter 2 (KCC2) in dorsal horn neurons induced by brain-derived neurotrophic factor (BDNF), causing neuronal disinh...

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Detalles Bibliográficos
Autores principales: Richner, Mette, Pallesen, Lone T., Ulrichsen, Maj, Poulsen, Ebbe T., Holm, Thomas H., Login, Hande, Castonguay, Annie, Lorenzo, Louis-Etienne, Gonçalves, Nádia P., Andersen, Olav M., Lykke-Hartmann, Karin, Enghild, Jan J., Rønn, Lars C. B., Malik, Ibrahim J., De Koninck, Yves, Bjerrum, Ole J., Vægter, Christian B., Nykjær, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584543/
https://www.ncbi.nlm.nih.gov/pubmed/31223654
http://dx.doi.org/10.1126/sciadv.aav9946

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