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FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer
Although invasive epithelial ovarian cancer (IOC) and low malignant potential ovarian tumour (LMP) are similar, they are associated with different outcomes and treatment strategies. The current accuracy in distinguishing these diseases is unsatisfactory, leading to delays or unnecessary treatments....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584551/ https://www.ncbi.nlm.nih.gov/pubmed/31037837 http://dx.doi.org/10.1111/jcmm.14360 |
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author | Zhang, Qingyu Yu, Shan Lok, Samson Ian Sam Wong, Alice Sze Tsai Jiao, Yufei Lee, Leo Tsz On |
author_facet | Zhang, Qingyu Yu, Shan Lok, Samson Ian Sam Wong, Alice Sze Tsai Jiao, Yufei Lee, Leo Tsz On |
author_sort | Zhang, Qingyu |
collection | PubMed |
description | Although invasive epithelial ovarian cancer (IOC) and low malignant potential ovarian tumour (LMP) are similar, they are associated with different outcomes and treatment strategies. The current accuracy in distinguishing these diseases is unsatisfactory, leading to delays or unnecessary treatments. We compared the molecular signature of IOC and LMP cases by analysing their transcriptomic data and re‐clustered them according to these data rather than the pathological dissection. We identified that FAM83D was highly expressed in IOC. To verify the role of FAM83D in the progression and metastasis, we used the isogenic ovarian cancer metastatic models, highly metastatic cells (HM) and non‐metastatic cells (NM). Overexpression of FAM83D significantly promoted cell proliferation, migration and spheroid formation. This was consistent with previous data showing that high FAM83D expression is associated with poor prognosis in cancer patients. Moreover, similar to the HM cells, the FAM83D‐overexpressing NM cells demonstrated stronger phosphorylation of the epidermal growth factor receptor (EGFR) and c‐Raf. This indicates that the action of FAM83D is mediated by the activation of the EGFR pathway. Taken together, this report suggested that FAM83D might be an excellent molecular marker to discriminate between IOC and LMP. |
format | Online Article Text |
id | pubmed-6584551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65845512019-07-01 FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer Zhang, Qingyu Yu, Shan Lok, Samson Ian Sam Wong, Alice Sze Tsai Jiao, Yufei Lee, Leo Tsz On J Cell Mol Med Original Articles Although invasive epithelial ovarian cancer (IOC) and low malignant potential ovarian tumour (LMP) are similar, they are associated with different outcomes and treatment strategies. The current accuracy in distinguishing these diseases is unsatisfactory, leading to delays or unnecessary treatments. We compared the molecular signature of IOC and LMP cases by analysing their transcriptomic data and re‐clustered them according to these data rather than the pathological dissection. We identified that FAM83D was highly expressed in IOC. To verify the role of FAM83D in the progression and metastasis, we used the isogenic ovarian cancer metastatic models, highly metastatic cells (HM) and non‐metastatic cells (NM). Overexpression of FAM83D significantly promoted cell proliferation, migration and spheroid formation. This was consistent with previous data showing that high FAM83D expression is associated with poor prognosis in cancer patients. Moreover, similar to the HM cells, the FAM83D‐overexpressing NM cells demonstrated stronger phosphorylation of the epidermal growth factor receptor (EGFR) and c‐Raf. This indicates that the action of FAM83D is mediated by the activation of the EGFR pathway. Taken together, this report suggested that FAM83D might be an excellent molecular marker to discriminate between IOC and LMP. John Wiley and Sons Inc. 2019-04-30 2019-07 /pmc/articles/PMC6584551/ /pubmed/31037837 http://dx.doi.org/10.1111/jcmm.14360 Text en © 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Zhang, Qingyu Yu, Shan Lok, Samson Ian Sam Wong, Alice Sze Tsai Jiao, Yufei Lee, Leo Tsz On FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer |
title | FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer |
title_full | FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer |
title_fullStr | FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer |
title_full_unstemmed | FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer |
title_short | FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer |
title_sort | fam83d promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584551/ https://www.ncbi.nlm.nih.gov/pubmed/31037837 http://dx.doi.org/10.1111/jcmm.14360 |
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