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FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer

Although invasive epithelial ovarian cancer (IOC) and low malignant potential ovarian tumour (LMP) are similar, they are associated with different outcomes and treatment strategies. The current accuracy in distinguishing these diseases is unsatisfactory, leading to delays or unnecessary treatments....

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Autores principales: Zhang, Qingyu, Yu, Shan, Lok, Samson Ian Sam, Wong, Alice Sze Tsai, Jiao, Yufei, Lee, Leo Tsz On
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584551/
https://www.ncbi.nlm.nih.gov/pubmed/31037837
http://dx.doi.org/10.1111/jcmm.14360
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author Zhang, Qingyu
Yu, Shan
Lok, Samson Ian Sam
Wong, Alice Sze Tsai
Jiao, Yufei
Lee, Leo Tsz On
author_facet Zhang, Qingyu
Yu, Shan
Lok, Samson Ian Sam
Wong, Alice Sze Tsai
Jiao, Yufei
Lee, Leo Tsz On
author_sort Zhang, Qingyu
collection PubMed
description Although invasive epithelial ovarian cancer (IOC) and low malignant potential ovarian tumour (LMP) are similar, they are associated with different outcomes and treatment strategies. The current accuracy in distinguishing these diseases is unsatisfactory, leading to delays or unnecessary treatments. We compared the molecular signature of IOC and LMP cases by analysing their transcriptomic data and re‐clustered them according to these data rather than the pathological dissection. We identified that FAM83D was highly expressed in IOC. To verify the role of FAM83D in the progression and metastasis, we used the isogenic ovarian cancer metastatic models, highly metastatic cells (HM) and non‐metastatic cells (NM). Overexpression of FAM83D significantly promoted cell proliferation, migration and spheroid formation. This was consistent with previous data showing that high FAM83D expression is associated with poor prognosis in cancer patients. Moreover, similar to the HM cells, the FAM83D‐overexpressing NM cells demonstrated stronger phosphorylation of the epidermal growth factor receptor (EGFR) and c‐Raf. This indicates that the action of FAM83D is mediated by the activation of the EGFR pathway. Taken together, this report suggested that FAM83D might be an excellent molecular marker to discriminate between IOC and LMP.
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spelling pubmed-65845512019-07-01 FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer Zhang, Qingyu Yu, Shan Lok, Samson Ian Sam Wong, Alice Sze Tsai Jiao, Yufei Lee, Leo Tsz On J Cell Mol Med Original Articles Although invasive epithelial ovarian cancer (IOC) and low malignant potential ovarian tumour (LMP) are similar, they are associated with different outcomes and treatment strategies. The current accuracy in distinguishing these diseases is unsatisfactory, leading to delays or unnecessary treatments. We compared the molecular signature of IOC and LMP cases by analysing their transcriptomic data and re‐clustered them according to these data rather than the pathological dissection. We identified that FAM83D was highly expressed in IOC. To verify the role of FAM83D in the progression and metastasis, we used the isogenic ovarian cancer metastatic models, highly metastatic cells (HM) and non‐metastatic cells (NM). Overexpression of FAM83D significantly promoted cell proliferation, migration and spheroid formation. This was consistent with previous data showing that high FAM83D expression is associated with poor prognosis in cancer patients. Moreover, similar to the HM cells, the FAM83D‐overexpressing NM cells demonstrated stronger phosphorylation of the epidermal growth factor receptor (EGFR) and c‐Raf. This indicates that the action of FAM83D is mediated by the activation of the EGFR pathway. Taken together, this report suggested that FAM83D might be an excellent molecular marker to discriminate between IOC and LMP. John Wiley and Sons Inc. 2019-04-30 2019-07 /pmc/articles/PMC6584551/ /pubmed/31037837 http://dx.doi.org/10.1111/jcmm.14360 Text en © 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Zhang, Qingyu
Yu, Shan
Lok, Samson Ian Sam
Wong, Alice Sze Tsai
Jiao, Yufei
Lee, Leo Tsz On
FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer
title FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer
title_full FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer
title_fullStr FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer
title_full_unstemmed FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer
title_short FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer
title_sort fam83d promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584551/
https://www.ncbi.nlm.nih.gov/pubmed/31037837
http://dx.doi.org/10.1111/jcmm.14360
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