SMPDL3b modulates insulin receptor signaling in diabetic kidney disease

Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme that regulates plasma membrane (PM) fluidity. Here we report that SMPDL3b excess, as observed in podocytes in diabetic kidney disease (DKD), impairs insulin receptor isoform B-dependent pro-survival insulin signaling by in...

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Detalles Bibliográficos
Autores principales: Mitrofanova, A., Mallela, S. K., Ducasa, G. M., Yoo, T. H., Rosenfeld-Gur, E., Zelnik, I. D., Molina, J., Varona Santos, J., Ge, M., Sloan, A., Kim, J. J., Pedigo, C., Bryn, J., Volosenco, I., Faul, C., Zeidan, Y. H., Garcia Hernandez, C., Mendez, A. J., Leibiger, I., Burke, G. W., Futerman, A. H., Barisoni, L., Ishimoto, Y., Inagi, R., Merscher, S., Fornoni, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584700/
https://www.ncbi.nlm.nih.gov/pubmed/31217420
http://dx.doi.org/10.1038/s41467-019-10584-4

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