Cargando…
Association Between Funisitis and Childhood Intellectual Development: A Prospective Cohort Study
Background: Previous studies have suggested that prenatal inflammation could damage the immature brain of preterm infants. In this study, we aimed to investigate whether funisitis could affect childhood neurodevelopment. We hypothesized that childhood neurodevelopment would vary across groups with o...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584799/ https://www.ncbi.nlm.nih.gov/pubmed/31263446 http://dx.doi.org/10.3389/fneur.2019.00612 |
_version_ | 1783428580248649728 |
---|---|
author | Liu, Chengbo Chen, Yan Zhao, Dongying Zhang, Jun Zhang, Yongjun |
author_facet | Liu, Chengbo Chen, Yan Zhao, Dongying Zhang, Jun Zhang, Yongjun |
author_sort | Liu, Chengbo |
collection | PubMed |
description | Background: Previous studies have suggested that prenatal inflammation could damage the immature brain of preterm infants. In this study, we aimed to investigate whether funisitis could affect childhood neurodevelopment. We hypothesized that childhood neurodevelopment would vary across groups with or without funisitis. Material sand Methods: Using data from the U.S. Collaborative Perinatal Project (1959–1976), 29,725 subjects with available intelligence quotient (IQ) were studied. Detailed placental examinations were conducted according to a standard protocol with quality control procedures. Multivariate logistic regression models were applied to evaluate the relationship between funisitis and IQ at age 4 or 7 years after adjusting for confounders. Results: Early preterm birth children with funisitis had a 3.0-fold (95% confidence interval 1.2, 7.3) risk of low full-scale IQ (<70) at age 4 years, which disappeared until age 7 years. Term birth children with funisitis had 1.9-fold (95% confidence interval 1.2, 3.0) risk of low performance IQ at age 7 years, but they did not have increased risk of low full-scale IQ. No difference in IQ score was found in late preterm birth children. Conclusion: Funisitis may injure the developmental brain of infants, leading to the relative low IQ in childhood at age 4, but the negative effect is only existed in performance IQ at age of 7. |
format | Online Article Text |
id | pubmed-6584799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65847992019-07-01 Association Between Funisitis and Childhood Intellectual Development: A Prospective Cohort Study Liu, Chengbo Chen, Yan Zhao, Dongying Zhang, Jun Zhang, Yongjun Front Neurol Neurology Background: Previous studies have suggested that prenatal inflammation could damage the immature brain of preterm infants. In this study, we aimed to investigate whether funisitis could affect childhood neurodevelopment. We hypothesized that childhood neurodevelopment would vary across groups with or without funisitis. Material sand Methods: Using data from the U.S. Collaborative Perinatal Project (1959–1976), 29,725 subjects with available intelligence quotient (IQ) were studied. Detailed placental examinations were conducted according to a standard protocol with quality control procedures. Multivariate logistic regression models were applied to evaluate the relationship between funisitis and IQ at age 4 or 7 years after adjusting for confounders. Results: Early preterm birth children with funisitis had a 3.0-fold (95% confidence interval 1.2, 7.3) risk of low full-scale IQ (<70) at age 4 years, which disappeared until age 7 years. Term birth children with funisitis had 1.9-fold (95% confidence interval 1.2, 3.0) risk of low performance IQ at age 7 years, but they did not have increased risk of low full-scale IQ. No difference in IQ score was found in late preterm birth children. Conclusion: Funisitis may injure the developmental brain of infants, leading to the relative low IQ in childhood at age 4, but the negative effect is only existed in performance IQ at age of 7. Frontiers Media S.A. 2019-06-11 /pmc/articles/PMC6584799/ /pubmed/31263446 http://dx.doi.org/10.3389/fneur.2019.00612 Text en Copyright © 2019 Liu, Chen, Zhao, Zhang and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Liu, Chengbo Chen, Yan Zhao, Dongying Zhang, Jun Zhang, Yongjun Association Between Funisitis and Childhood Intellectual Development: A Prospective Cohort Study |
title | Association Between Funisitis and Childhood Intellectual Development: A Prospective Cohort Study |
title_full | Association Between Funisitis and Childhood Intellectual Development: A Prospective Cohort Study |
title_fullStr | Association Between Funisitis and Childhood Intellectual Development: A Prospective Cohort Study |
title_full_unstemmed | Association Between Funisitis and Childhood Intellectual Development: A Prospective Cohort Study |
title_short | Association Between Funisitis and Childhood Intellectual Development: A Prospective Cohort Study |
title_sort | association between funisitis and childhood intellectual development: a prospective cohort study |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584799/ https://www.ncbi.nlm.nih.gov/pubmed/31263446 http://dx.doi.org/10.3389/fneur.2019.00612 |
work_keys_str_mv | AT liuchengbo associationbetweenfunisitisandchildhoodintellectualdevelopmentaprospectivecohortstudy AT chenyan associationbetweenfunisitisandchildhoodintellectualdevelopmentaprospectivecohortstudy AT zhaodongying associationbetweenfunisitisandchildhoodintellectualdevelopmentaprospectivecohortstudy AT zhangjun associationbetweenfunisitisandchildhoodintellectualdevelopmentaprospectivecohortstudy AT zhangyongjun associationbetweenfunisitisandchildhoodintellectualdevelopmentaprospectivecohortstudy |