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C8-Substituted Imidazotetrazine Analogs Overcome Temozolomide Resistance by Inducing DNA Adducts and DNA Damage

Temozolomide (TMZ) is the standard of care chemotherapeutic agent used in the treatment of glioblastoma multiforme. Cytotoxic O6-methylguaine lesions formed by TMZ are repaired by O6-methyl-guanine DNA methyltransferase (MGMT), a DNA repair protein that removes alkyl groups located at the O6-positio...

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Detalles Bibliográficos
Autores principales:	Yang, Zhikuan, Wei, Danping, Dai, Xiaoli, Stevens, Malcolm F. G., Bradshaw, Tracey D., Luo, Ying, Zhang, Jihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584802/ https://www.ncbi.nlm.nih.gov/pubmed/31263673 http://dx.doi.org/10.3389/fonc.2019.00485

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