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Isocitrate Dehydrogenase Mutations in Glioma: From Basic Discovery to Therapeutics Development
Isocitrate dehydrogenase (IDH) is a key rate-limiting enzyme in the Krebs cycle that plays an important role in energy metabolism. In recent years, it has been found that IDH mutations are closely related to the occurrence and development of glioma, and it is a notable potential therapeutic target....
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584818/ https://www.ncbi.nlm.nih.gov/pubmed/31263678 http://dx.doi.org/10.3389/fonc.2019.00506 |