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Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling
Receptor tyrosine kinase (RTK)-mediated hyperactivation of the MAPK/Erk pathway is responsible for a large number of pathogenic outcomes including many cancers. Considerable effort has been directed at targeting this pathway with varying degrees of long term therapeutic success. Under non-stimulated...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science Ireland
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584941/ https://www.ncbi.nlm.nih.gov/pubmed/31100409 http://dx.doi.org/10.1016/j.canlet.2019.05.008 |