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Active repurposing of drug candidates for melanoma based on GWAS, PheWAS and a wide range of omics data
BACKGROUND: Drug repurposing is a swift, safe, and cheap drug discovery method. Melanoma disorders present low survival and high mortality rates and are challenging to diagnose and treat. Moreover, there is a high volume of worldwide investigations that are attempting to find melanoma-related genes...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584997/ https://www.ncbi.nlm.nih.gov/pubmed/31221082 http://dx.doi.org/10.1186/s10020-019-0098-x |
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author | Khosravi, Ali Jayaram, B. Goliaei, Bahram Masoudi-Nejad, Ali |
author_facet | Khosravi, Ali Jayaram, B. Goliaei, Bahram Masoudi-Nejad, Ali |
author_sort | Khosravi, Ali |
collection | PubMed |
description | BACKGROUND: Drug repurposing is a swift, safe, and cheap drug discovery method. Melanoma disorders present low survival and high mortality rates and are challenging to diagnose and treat. Moreover, there is a high volume of worldwide investigations that are attempting to find melanoma-related genes of influence, which can be identified as responsive targets for reliable treatment. METHOD: In this study, we used a wide range of data analyses to analyze over 1100 genes and proteins of influence with respect to cutaneous malignant melanoma. Our analysis included various investigational results from genome- and phenome-wide association studies (GWAS and PheWAS, respectively), biomedical, transcriptomic, and metabolomic datasets. We then researched the DrugBank for potential melanoma targets from the selected list. We excluded known melanoma targets to obtain a list of druggable proteins. We performed a precise analysis of the drugs’ pathogenesis and checked the expression profiles of the selected drugs having high associations with known anti-melanoma drugs. RESULT: We found 35 drugs that interacted with 20 unique targets. These drugs appear to have high melanoma treatment potentials. We confirmed our results with previous studies and found supporting references for 30 of these drugs. In conclusion, this investigation can be applied to various diseases for the efficient and economical repurposing of various drug compounds. For further validation, the results may be applicable for in vivo tests and clinical trials. |
format | Online Article Text |
id | pubmed-6584997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-65849972019-06-27 Active repurposing of drug candidates for melanoma based on GWAS, PheWAS and a wide range of omics data Khosravi, Ali Jayaram, B. Goliaei, Bahram Masoudi-Nejad, Ali Mol Med Research Article BACKGROUND: Drug repurposing is a swift, safe, and cheap drug discovery method. Melanoma disorders present low survival and high mortality rates and are challenging to diagnose and treat. Moreover, there is a high volume of worldwide investigations that are attempting to find melanoma-related genes of influence, which can be identified as responsive targets for reliable treatment. METHOD: In this study, we used a wide range of data analyses to analyze over 1100 genes and proteins of influence with respect to cutaneous malignant melanoma. Our analysis included various investigational results from genome- and phenome-wide association studies (GWAS and PheWAS, respectively), biomedical, transcriptomic, and metabolomic datasets. We then researched the DrugBank for potential melanoma targets from the selected list. We excluded known melanoma targets to obtain a list of druggable proteins. We performed a precise analysis of the drugs’ pathogenesis and checked the expression profiles of the selected drugs having high associations with known anti-melanoma drugs. RESULT: We found 35 drugs that interacted with 20 unique targets. These drugs appear to have high melanoma treatment potentials. We confirmed our results with previous studies and found supporting references for 30 of these drugs. In conclusion, this investigation can be applied to various diseases for the efficient and economical repurposing of various drug compounds. For further validation, the results may be applicable for in vivo tests and clinical trials. BioMed Central 2019-06-20 /pmc/articles/PMC6584997/ /pubmed/31221082 http://dx.doi.org/10.1186/s10020-019-0098-x Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Khosravi, Ali Jayaram, B. Goliaei, Bahram Masoudi-Nejad, Ali Active repurposing of drug candidates for melanoma based on GWAS, PheWAS and a wide range of omics data |
title | Active repurposing of drug candidates for melanoma based on GWAS, PheWAS and a wide range of omics data |
title_full | Active repurposing of drug candidates for melanoma based on GWAS, PheWAS and a wide range of omics data |
title_fullStr | Active repurposing of drug candidates for melanoma based on GWAS, PheWAS and a wide range of omics data |
title_full_unstemmed | Active repurposing of drug candidates for melanoma based on GWAS, PheWAS and a wide range of omics data |
title_short | Active repurposing of drug candidates for melanoma based on GWAS, PheWAS and a wide range of omics data |
title_sort | active repurposing of drug candidates for melanoma based on gwas, phewas and a wide range of omics data |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584997/ https://www.ncbi.nlm.nih.gov/pubmed/31221082 http://dx.doi.org/10.1186/s10020-019-0098-x |
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