A case of DAPSONE INDUCED METHEMOGLOBINEMIA

Methemoglobinemia (MetHb) being a rare cause of cyanosis is generally not considered in its differential diagnosis. Methemoglobinemia is an abnormal Hb produced physiologically by auto-oxidation. If this process of auto oxidation is impaired either due to genetic defect or due to exogenous drugs/ to...

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Detalles Bibliográficos
Autores principales: Mahmood, Najia, Khan, Mutti Ullah, Haq, Ihtisham U. L., Jelani, Farhat Afshan, Tariq, Aayesha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585036/
https://www.ncbi.nlm.nih.gov/pubmed/31249693
http://dx.doi.org/10.1186/s40545-019-0185-y
Descripción
Sumario:Methemoglobinemia (MetHb) being a rare cause of cyanosis is generally not considered in its differential diagnosis. Methemoglobinemia is an abnormal Hb produced physiologically by auto-oxidation. If this process of auto oxidation is impaired either due to genetic defect or due to exogenous drugs/ toxins, its level starts rising. Once it is > 3%, tissue hypoxia ensues. Here is a case of dapsone induced MetHb and is reported in a young girl with central cyanosis, and was treated successfully with methylene blue. Methemoglobinemia should be considered in differential diagnoses of cyanosed patient with normal ABGs, PaO(2) and cardio-respiratory status. If left untreated, the disease can be fatal.

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