A case of DAPSONE INDUCED METHEMOGLOBINEMIA

Methemoglobinemia (MetHb) being a rare cause of cyanosis is generally not considered in its differential diagnosis. Methemoglobinemia is an abnormal Hb produced physiologically by auto-oxidation. If this process of auto oxidation is impaired either due to genetic defect or due to exogenous drugs/ to...

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Autores principales: Mahmood, Najia, Khan, Mutti Ullah, Haq, Ihtisham U. L., Jelani, Farhat Afshan, Tariq, Aayesha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585036/
https://www.ncbi.nlm.nih.gov/pubmed/31249693
http://dx.doi.org/10.1186/s40545-019-0185-y
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author Mahmood, Najia
Khan, Mutti Ullah
Haq, Ihtisham U. L.
Jelani, Farhat Afshan
Tariq, Aayesha
author_facet Mahmood, Najia
Khan, Mutti Ullah
Haq, Ihtisham U. L.
Jelani, Farhat Afshan
Tariq, Aayesha
author_sort Mahmood, Najia
collection PubMed
description Methemoglobinemia (MetHb) being a rare cause of cyanosis is generally not considered in its differential diagnosis. Methemoglobinemia is an abnormal Hb produced physiologically by auto-oxidation. If this process of auto oxidation is impaired either due to genetic defect or due to exogenous drugs/ toxins, its level starts rising. Once it is > 3%, tissue hypoxia ensues. Here is a case of dapsone induced MetHb and is reported in a young girl with central cyanosis, and was treated successfully with methylene blue. Methemoglobinemia should be considered in differential diagnoses of cyanosed patient with normal ABGs, PaO(2) and cardio-respiratory status. If left untreated, the disease can be fatal.
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spelling pubmed-65850362019-06-27 A case of DAPSONE INDUCED METHEMOGLOBINEMIA Mahmood, Najia Khan, Mutti Ullah Haq, Ihtisham U. L. Jelani, Farhat Afshan Tariq, Aayesha J Pharm Policy Pract Short Report Methemoglobinemia (MetHb) being a rare cause of cyanosis is generally not considered in its differential diagnosis. Methemoglobinemia is an abnormal Hb produced physiologically by auto-oxidation. If this process of auto oxidation is impaired either due to genetic defect or due to exogenous drugs/ toxins, its level starts rising. Once it is > 3%, tissue hypoxia ensues. Here is a case of dapsone induced MetHb and is reported in a young girl with central cyanosis, and was treated successfully with methylene blue. Methemoglobinemia should be considered in differential diagnoses of cyanosed patient with normal ABGs, PaO(2) and cardio-respiratory status. If left untreated, the disease can be fatal. BioMed Central 2019-06-20 /pmc/articles/PMC6585036/ /pubmed/31249693 http://dx.doi.org/10.1186/s40545-019-0185-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Mahmood, Najia
Khan, Mutti Ullah
Haq, Ihtisham U. L.
Jelani, Farhat Afshan
Tariq, Aayesha
A case of DAPSONE INDUCED METHEMOGLOBINEMIA
title A case of DAPSONE INDUCED METHEMOGLOBINEMIA
title_full A case of DAPSONE INDUCED METHEMOGLOBINEMIA
title_fullStr A case of DAPSONE INDUCED METHEMOGLOBINEMIA
title_full_unstemmed A case of DAPSONE INDUCED METHEMOGLOBINEMIA
title_short A case of DAPSONE INDUCED METHEMOGLOBINEMIA
title_sort case of dapsone induced methemoglobinemia
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585036/
https://www.ncbi.nlm.nih.gov/pubmed/31249693
http://dx.doi.org/10.1186/s40545-019-0185-y
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