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Inflammatory patterns of antrochoanal polyps in the pediatric age group
BACKGROUND: The pathogenesis and etiology of antrochoanal polyps (ACPs) remains obscure. This study aimed to characterize the inflammatory profiles and investigate the effect of atopy on the pathogenesis of pediatric ACPs. METHODS: Thirty-three ACP patients and ten control subjects were enrolled fro...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585040/ https://www.ncbi.nlm.nih.gov/pubmed/31249603 http://dx.doi.org/10.1186/s13223-019-0352-3 |
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author | Zheng, Huiwen Tang, Lixing Song, Beibei Yang, Xiaojian Chu, Ping Han, Shujing Wang, Pengpeng Lu, Jie Ge, Wentong Ni, Xin |
author_facet | Zheng, Huiwen Tang, Lixing Song, Beibei Yang, Xiaojian Chu, Ping Han, Shujing Wang, Pengpeng Lu, Jie Ge, Wentong Ni, Xin |
author_sort | Zheng, Huiwen |
collection | PubMed |
description | BACKGROUND: The pathogenesis and etiology of antrochoanal polyps (ACPs) remains obscure. This study aimed to characterize the inflammatory profiles and investigate the effect of atopy on the pathogenesis of pediatric ACPs. METHODS: Thirty-three ACP patients and ten control subjects were enrolled from January to December 2017. The severity of individual nasal symptoms was scored on a visual analogue scale (VAS). The serum total immunoglobulin E (IgE) and cytokines level was measured by multiplexed luminex assay. RESULTS: There was no significant difference in VAS scores and counts of inflammatory cells between atopic and nonatopic ACP. No difference in IFNγ, IL-4, IL-5, IL-13, IL-17A and IL-25 was found between control and whole ACP, nonatopic and atopic ACP. Significantly increased levels of IL-6 and IL-10 were found in ACP compared with control. For neutrophil chemotactic factor, significant increases of IL-8 and GRO were observed in ACP, but for eosinophil chemotactic factor, no difference was found in RANTES and GM-CSF. IL-6 level was positively correlated with IL-8, MCP1, and GRO level, and IL-10 level was positively correlated with IL-4 and IL-13 in ACP subjects. CONCLUSION: Nasal obstruction was the most common symptom in ACPs in children. Allergic condition may have a poor role in the pathogenesis of ACPs. IL-6 plays a crucial role in the pathogenesis of neutrophilic inflammation in patients with ACPs and may provide a new treatment strategy for ACPs in children. Treg cell associated cytokine IL-10 was involved in the inflammatory pathophysiological process of ACPs and played a certain regulatory role. |
format | Online Article Text |
id | pubmed-6585040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-65850402019-06-27 Inflammatory patterns of antrochoanal polyps in the pediatric age group Zheng, Huiwen Tang, Lixing Song, Beibei Yang, Xiaojian Chu, Ping Han, Shujing Wang, Pengpeng Lu, Jie Ge, Wentong Ni, Xin Allergy Asthma Clin Immunol Research BACKGROUND: The pathogenesis and etiology of antrochoanal polyps (ACPs) remains obscure. This study aimed to characterize the inflammatory profiles and investigate the effect of atopy on the pathogenesis of pediatric ACPs. METHODS: Thirty-three ACP patients and ten control subjects were enrolled from January to December 2017. The severity of individual nasal symptoms was scored on a visual analogue scale (VAS). The serum total immunoglobulin E (IgE) and cytokines level was measured by multiplexed luminex assay. RESULTS: There was no significant difference in VAS scores and counts of inflammatory cells between atopic and nonatopic ACP. No difference in IFNγ, IL-4, IL-5, IL-13, IL-17A and IL-25 was found between control and whole ACP, nonatopic and atopic ACP. Significantly increased levels of IL-6 and IL-10 were found in ACP compared with control. For neutrophil chemotactic factor, significant increases of IL-8 and GRO were observed in ACP, but for eosinophil chemotactic factor, no difference was found in RANTES and GM-CSF. IL-6 level was positively correlated with IL-8, MCP1, and GRO level, and IL-10 level was positively correlated with IL-4 and IL-13 in ACP subjects. CONCLUSION: Nasal obstruction was the most common symptom in ACPs in children. Allergic condition may have a poor role in the pathogenesis of ACPs. IL-6 plays a crucial role in the pathogenesis of neutrophilic inflammation in patients with ACPs and may provide a new treatment strategy for ACPs in children. Treg cell associated cytokine IL-10 was involved in the inflammatory pathophysiological process of ACPs and played a certain regulatory role. BioMed Central 2019-06-20 /pmc/articles/PMC6585040/ /pubmed/31249603 http://dx.doi.org/10.1186/s13223-019-0352-3 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Zheng, Huiwen Tang, Lixing Song, Beibei Yang, Xiaojian Chu, Ping Han, Shujing Wang, Pengpeng Lu, Jie Ge, Wentong Ni, Xin Inflammatory patterns of antrochoanal polyps in the pediatric age group |
title | Inflammatory patterns of antrochoanal polyps in the pediatric age group |
title_full | Inflammatory patterns of antrochoanal polyps in the pediatric age group |
title_fullStr | Inflammatory patterns of antrochoanal polyps in the pediatric age group |
title_full_unstemmed | Inflammatory patterns of antrochoanal polyps in the pediatric age group |
title_short | Inflammatory patterns of antrochoanal polyps in the pediatric age group |
title_sort | inflammatory patterns of antrochoanal polyps in the pediatric age group |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585040/ https://www.ncbi.nlm.nih.gov/pubmed/31249603 http://dx.doi.org/10.1186/s13223-019-0352-3 |
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