Mechanisms of immune-related adverse events associated with immune checkpoint blockade: using germline genetics to develop a personalized approach

Personalized care of cancer patients undergoing treatment with immune checkpoint inhibitors will require approaches that can predict their susceptibility to immune-related adverse events. Understanding the role of germline genetic factors in determining individual responses to immunotherapy will dee...

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Detalles Bibliográficos
Autores principales: Khan, Zia, Hammer, Christian, Guardino, Ellie, Chandler, G. Scott, Albert, Matthew L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585053/
https://www.ncbi.nlm.nih.gov/pubmed/31221204
http://dx.doi.org/10.1186/s13073-019-0652-8
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author Khan, Zia
Hammer, Christian
Guardino, Ellie
Chandler, G. Scott
Albert, Matthew L.
author_facet Khan, Zia
Hammer, Christian
Guardino, Ellie
Chandler, G. Scott
Albert, Matthew L.
author_sort Khan, Zia
collection PubMed
description Personalized care of cancer patients undergoing treatment with immune checkpoint inhibitors will require approaches that can predict their susceptibility to immune-related adverse events. Understanding the role of germline genetic factors in determining individual responses to immunotherapy will deepen our understanding of immune toxicity and, importantly, it may lead to tools for identifying patients who are at risk.
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spelling pubmed-65850532019-06-27 Mechanisms of immune-related adverse events associated with immune checkpoint blockade: using germline genetics to develop a personalized approach Khan, Zia Hammer, Christian Guardino, Ellie Chandler, G. Scott Albert, Matthew L. Genome Med Comment Personalized care of cancer patients undergoing treatment with immune checkpoint inhibitors will require approaches that can predict their susceptibility to immune-related adverse events. Understanding the role of germline genetic factors in determining individual responses to immunotherapy will deepen our understanding of immune toxicity and, importantly, it may lead to tools for identifying patients who are at risk. BioMed Central 2019-06-20 /pmc/articles/PMC6585053/ /pubmed/31221204 http://dx.doi.org/10.1186/s13073-019-0652-8 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Khan, Zia
Hammer, Christian
Guardino, Ellie
Chandler, G. Scott
Albert, Matthew L.
Mechanisms of immune-related adverse events associated with immune checkpoint blockade: using germline genetics to develop a personalized approach
title Mechanisms of immune-related adverse events associated with immune checkpoint blockade: using germline genetics to develop a personalized approach
title_full Mechanisms of immune-related adverse events associated with immune checkpoint blockade: using germline genetics to develop a personalized approach
title_fullStr Mechanisms of immune-related adverse events associated with immune checkpoint blockade: using germline genetics to develop a personalized approach
title_full_unstemmed Mechanisms of immune-related adverse events associated with immune checkpoint blockade: using germline genetics to develop a personalized approach
title_short Mechanisms of immune-related adverse events associated with immune checkpoint blockade: using germline genetics to develop a personalized approach
title_sort mechanisms of immune-related adverse events associated with immune checkpoint blockade: using germline genetics to develop a personalized approach
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585053/
https://www.ncbi.nlm.nih.gov/pubmed/31221204
http://dx.doi.org/10.1186/s13073-019-0652-8
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