Telomere Length: A Potential Biomarker for the Risk and Prognosis of Stroke

Stroke is one of the leading causes of death and disability worldwide. Age is associated with increased risk of stroke, while telomere length shortening plays a pivotal role in the process of aging. Moreover, telomere length shortening is associated with many risk factors of stroke in addition to ag...

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Autores principales: Tian, Yanjun, Wang, Shuai, Jiao, Fengjuan, Kong, Qingsheng, Liu, Chuanxin, Wu, Yili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585102/
https://www.ncbi.nlm.nih.gov/pubmed/31263449
http://dx.doi.org/10.3389/fneur.2019.00624
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author Tian, Yanjun
Wang, Shuai
Jiao, Fengjuan
Kong, Qingsheng
Liu, Chuanxin
Wu, Yili
author_facet Tian, Yanjun
Wang, Shuai
Jiao, Fengjuan
Kong, Qingsheng
Liu, Chuanxin
Wu, Yili
author_sort Tian, Yanjun
collection PubMed
description Stroke is one of the leading causes of death and disability worldwide. Age is associated with increased risk of stroke, while telomere length shortening plays a pivotal role in the process of aging. Moreover, telomere length shortening is associated with many risk factors of stroke in addition to age. Accumulated evidence shows that short leukocyte telomere length is not only associated with stroke occurrence but also associated with post-stroke recovery in the elderly population. In this review, we aimed to summarize the association between leukocyte telomere length and stroke, and discuss that telomere length might serve as a potential biomarker to predict the risk and prognosis of stroke.
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spelling pubmed-65851022019-07-01 Telomere Length: A Potential Biomarker for the Risk and Prognosis of Stroke Tian, Yanjun Wang, Shuai Jiao, Fengjuan Kong, Qingsheng Liu, Chuanxin Wu, Yili Front Neurol Neurology Stroke is one of the leading causes of death and disability worldwide. Age is associated with increased risk of stroke, while telomere length shortening plays a pivotal role in the process of aging. Moreover, telomere length shortening is associated with many risk factors of stroke in addition to age. Accumulated evidence shows that short leukocyte telomere length is not only associated with stroke occurrence but also associated with post-stroke recovery in the elderly population. In this review, we aimed to summarize the association between leukocyte telomere length and stroke, and discuss that telomere length might serve as a potential biomarker to predict the risk and prognosis of stroke. Frontiers Media S.A. 2019-06-13 /pmc/articles/PMC6585102/ /pubmed/31263449 http://dx.doi.org/10.3389/fneur.2019.00624 Text en Copyright © 2019 Tian, Wang, Jiao, Kong, Liu and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Tian, Yanjun
Wang, Shuai
Jiao, Fengjuan
Kong, Qingsheng
Liu, Chuanxin
Wu, Yili
Telomere Length: A Potential Biomarker for the Risk and Prognosis of Stroke
title Telomere Length: A Potential Biomarker for the Risk and Prognosis of Stroke
title_full Telomere Length: A Potential Biomarker for the Risk and Prognosis of Stroke
title_fullStr Telomere Length: A Potential Biomarker for the Risk and Prognosis of Stroke
title_full_unstemmed Telomere Length: A Potential Biomarker for the Risk and Prognosis of Stroke
title_short Telomere Length: A Potential Biomarker for the Risk and Prognosis of Stroke
title_sort telomere length: a potential biomarker for the risk and prognosis of stroke
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585102/
https://www.ncbi.nlm.nih.gov/pubmed/31263449
http://dx.doi.org/10.3389/fneur.2019.00624
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AT kongqingsheng telomerelengthapotentialbiomarkerfortheriskandprognosisofstroke
AT liuchuanxin telomerelengthapotentialbiomarkerfortheriskandprognosisofstroke
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