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Proteomics and phosphoproteomics in precision medicine: applications and challenges

Recent advances in proteomics allow the accurate measurement of abundances for thousands of proteins and phosphoproteins from multiple samples in parallel. Therefore, for the first time, we have the opportunity to measure the proteomic profiles of thousands of patient samples or disease model cell l...

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Detalles Bibliográficos
Autores principales: Giudice, Girolamo, Petsalaki, Evangelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585152/
https://www.ncbi.nlm.nih.gov/pubmed/29077858
http://dx.doi.org/10.1093/bib/bbx141
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author Giudice, Girolamo
Petsalaki, Evangelia
author_facet Giudice, Girolamo
Petsalaki, Evangelia
author_sort Giudice, Girolamo
collection PubMed
description Recent advances in proteomics allow the accurate measurement of abundances for thousands of proteins and phosphoproteins from multiple samples in parallel. Therefore, for the first time, we have the opportunity to measure the proteomic profiles of thousands of patient samples or disease model cell lines in a systematic way, to identify the precise underlying molecular mechanism and discover personalized biomarkers, networks and treatments. Here, we review examples of successful use of proteomics and phosphoproteomics data sets in as well as their integration other omics data sets with the aim of precision medicine. We will discuss the bioinformatics challenges posed by the generation, analysis and integration of such large data sets and present potential reasons why proteomics profiling and biomarkers are not currently widely used in the clinical setting. We will finally discuss ways to contribute to the better use of proteomics data in precision medicine and the clinical setting.
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spelling pubmed-65851522019-06-25 Proteomics and phosphoproteomics in precision medicine: applications and challenges Giudice, Girolamo Petsalaki, Evangelia Brief Bioinform Paper Recent advances in proteomics allow the accurate measurement of abundances for thousands of proteins and phosphoproteins from multiple samples in parallel. Therefore, for the first time, we have the opportunity to measure the proteomic profiles of thousands of patient samples or disease model cell lines in a systematic way, to identify the precise underlying molecular mechanism and discover personalized biomarkers, networks and treatments. Here, we review examples of successful use of proteomics and phosphoproteomics data sets in as well as their integration other omics data sets with the aim of precision medicine. We will discuss the bioinformatics challenges posed by the generation, analysis and integration of such large data sets and present potential reasons why proteomics profiling and biomarkers are not currently widely used in the clinical setting. We will finally discuss ways to contribute to the better use of proteomics data in precision medicine and the clinical setting. Oxford University Press 2017-10-25 /pmc/articles/PMC6585152/ /pubmed/29077858 http://dx.doi.org/10.1093/bib/bbx141 Text en © The Author 2017. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Paper
Giudice, Girolamo
Petsalaki, Evangelia
Proteomics and phosphoproteomics in precision medicine: applications and challenges
title Proteomics and phosphoproteomics in precision medicine: applications and challenges
title_full Proteomics and phosphoproteomics in precision medicine: applications and challenges
title_fullStr Proteomics and phosphoproteomics in precision medicine: applications and challenges
title_full_unstemmed Proteomics and phosphoproteomics in precision medicine: applications and challenges
title_short Proteomics and phosphoproteomics in precision medicine: applications and challenges
title_sort proteomics and phosphoproteomics in precision medicine: applications and challenges
topic Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585152/
https://www.ncbi.nlm.nih.gov/pubmed/29077858
http://dx.doi.org/10.1093/bib/bbx141
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