Lack of Fractalkine Receptor on Macrophages Impairs Spontaneous Recovery of Ribbon Synapses After Moderate Noise Trauma in C57BL/6 Mice

Noise trauma causes loss of synaptic connections between cochlear inner hair cells (IHCs) and the spiral ganglion neurons (SGNs). Such synaptic loss can trigger slow and progressive degeneration of SGNs. Macrophage fractalkine signaling is critical for neuron survival in the injured cochlea, but its...

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Detalles Bibliográficos
Autores principales: Kaur, Tejbeer, Clayman, Anna C., Nash, Andrew J., Schrader, Angela D., Warchol, Mark E., Ohlemiller, Kevin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585312/
https://www.ncbi.nlm.nih.gov/pubmed/31263398
http://dx.doi.org/10.3389/fnins.2019.00620

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