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Modulation of Fronto-Striatal Functional Connectivity Using Transcranial Magnetic Stimulation
Background: The fronto-striatal network is involved in various motor, cognitive, and emotional processes, such as spatial attention, working memory, decision-making, and emotion regulation. Intermittent theta burst transcranial magnetic stimulation (iTBS) has been shown to modulate functional connec...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585467/ https://www.ncbi.nlm.nih.gov/pubmed/31263404 http://dx.doi.org/10.3389/fnhum.2019.00190 |
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author | Alkhasli, Isabel Sakreida, Katrin Mottaghy, Felix M. Binkofski, Ferdinand |
author_facet | Alkhasli, Isabel Sakreida, Katrin Mottaghy, Felix M. Binkofski, Ferdinand |
author_sort | Alkhasli, Isabel |
collection | PubMed |
description | Background: The fronto-striatal network is involved in various motor, cognitive, and emotional processes, such as spatial attention, working memory, decision-making, and emotion regulation. Intermittent theta burst transcranial magnetic stimulation (iTBS) has been shown to modulate functional connectivity of brain networks. Long stimulation intervals, as well as high stimulation intensities are typically applied in transcranial magnetic stimulation (TMS) therapy for mood disorders. The role of stimulation intensity on network function and homeostasis has not been explored systematically yet. Objective: In this pilot study, we aimed to modulate fronto-striatal connectivity by applying iTBS at different intensities to the left dorso-lateral prefrontal cortex (DLPFC). We measured individual and group changes by comparing resting state functional magnetic resonance imaging (rsfMRI) both pre-iTBS and post-iTBS. Differential effects of individual sub- vs. supra-resting motor-threshold stimulation intensities were assessed. Methods: Sixteen healthy subjects underwent excitatory iTBS at two intensities [90% and 120% of individual resting motor threshold (rMT)] on separate days. Six-hundred pulses (2 s trains, 8 s pauses, duration of 3 min, 20 s) were applied over the left DLPFC. Directly before and 7 min after stimulation, task-free rsfMRI sessions, lasting 10 min each, were conducted. Individual seed-to-seed functional connectivity changes were calculated for 10 fronto-striatal and amygdala regions of interest with the SPM toolbox DPABI. Results: Sub-threshold-iTBS increased functional connectivity directly between the left DLPFC and the left and right caudate, respectively. Supra-threshold stimulation did not change fronto-striatal functional connectivity but increased functional connectivity between the right amygdala and the right caudate. Conclusion: A short iTBS protocol applied at sub-threshold intensities was not only sufficient, but favorable, in order to increase bilateral fronto-striatal functional connectivity, while minimizing side effects. The absence of an increase in functional connectivity after supra-threshold stimulation was possibly caused by network homeostatic effects. |
format | Online Article Text |
id | pubmed-6585467 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65854672019-07-01 Modulation of Fronto-Striatal Functional Connectivity Using Transcranial Magnetic Stimulation Alkhasli, Isabel Sakreida, Katrin Mottaghy, Felix M. Binkofski, Ferdinand Front Hum Neurosci Neuroscience Background: The fronto-striatal network is involved in various motor, cognitive, and emotional processes, such as spatial attention, working memory, decision-making, and emotion regulation. Intermittent theta burst transcranial magnetic stimulation (iTBS) has been shown to modulate functional connectivity of brain networks. Long stimulation intervals, as well as high stimulation intensities are typically applied in transcranial magnetic stimulation (TMS) therapy for mood disorders. The role of stimulation intensity on network function and homeostasis has not been explored systematically yet. Objective: In this pilot study, we aimed to modulate fronto-striatal connectivity by applying iTBS at different intensities to the left dorso-lateral prefrontal cortex (DLPFC). We measured individual and group changes by comparing resting state functional magnetic resonance imaging (rsfMRI) both pre-iTBS and post-iTBS. Differential effects of individual sub- vs. supra-resting motor-threshold stimulation intensities were assessed. Methods: Sixteen healthy subjects underwent excitatory iTBS at two intensities [90% and 120% of individual resting motor threshold (rMT)] on separate days. Six-hundred pulses (2 s trains, 8 s pauses, duration of 3 min, 20 s) were applied over the left DLPFC. Directly before and 7 min after stimulation, task-free rsfMRI sessions, lasting 10 min each, were conducted. Individual seed-to-seed functional connectivity changes were calculated for 10 fronto-striatal and amygdala regions of interest with the SPM toolbox DPABI. Results: Sub-threshold-iTBS increased functional connectivity directly between the left DLPFC and the left and right caudate, respectively. Supra-threshold stimulation did not change fronto-striatal functional connectivity but increased functional connectivity between the right amygdala and the right caudate. Conclusion: A short iTBS protocol applied at sub-threshold intensities was not only sufficient, but favorable, in order to increase bilateral fronto-striatal functional connectivity, while minimizing side effects. The absence of an increase in functional connectivity after supra-threshold stimulation was possibly caused by network homeostatic effects. Frontiers Media S.A. 2019-06-13 /pmc/articles/PMC6585467/ /pubmed/31263404 http://dx.doi.org/10.3389/fnhum.2019.00190 Text en Copyright © 2019 Alkhasli, Sakreida, Mottaghy and Binkofski. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Alkhasli, Isabel Sakreida, Katrin Mottaghy, Felix M. Binkofski, Ferdinand Modulation of Fronto-Striatal Functional Connectivity Using Transcranial Magnetic Stimulation |
title | Modulation of Fronto-Striatal Functional Connectivity Using Transcranial Magnetic Stimulation |
title_full | Modulation of Fronto-Striatal Functional Connectivity Using Transcranial Magnetic Stimulation |
title_fullStr | Modulation of Fronto-Striatal Functional Connectivity Using Transcranial Magnetic Stimulation |
title_full_unstemmed | Modulation of Fronto-Striatal Functional Connectivity Using Transcranial Magnetic Stimulation |
title_short | Modulation of Fronto-Striatal Functional Connectivity Using Transcranial Magnetic Stimulation |
title_sort | modulation of fronto-striatal functional connectivity using transcranial magnetic stimulation |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585467/ https://www.ncbi.nlm.nih.gov/pubmed/31263404 http://dx.doi.org/10.3389/fnhum.2019.00190 |
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