In vitro and in vivo Human Metabolism of (S)-[(18)F]Fluspidine – A Radioligand for Imaging σ(1) Receptors With Positron Emission Tomography (PET)

(S)-[(18)F]fluspidine ((S)-[(18)F]1) has recently been explored for positron emission tomography (PET) imaging of sigma-1 receptors in humans. In the current report, we have used plasma samples of healthy volunteers to investigate the radiometabolites of (S)-[(18)F]1 and elucidate their structures w...

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Detalles Bibliográficos
Autores principales: Ludwig, Friedrich-Alexander, Fischer, Steffen, Houska, Richard, Hoepping, Alexander, Deuther-Conrad, Winnie, Schepmann, Dirk, Patt, Marianne, Meyer, Philipp M., Hesse, Swen, Becker, Georg-Alexander, Zientek, Franziska Ruth, Steinbach, Jörg, Wünsch, Bernhard, Sabri, Osama, Brust, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585474/
https://www.ncbi.nlm.nih.gov/pubmed/31263411
http://dx.doi.org/10.3389/fphar.2019.00534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585474/
https://www.ncbi.nlm.nih.gov/pubmed/31263411
http://dx.doi.org/10.3389/fphar.2019.00534

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