Possible Protective Role of Panax Ginseng on Cisplatin-Induced Hepatotoxicity in Adult Male Albino Rats (Biochemical and Histological Study)

BACKGROUND: Cisplatin is one of the most effective chemotherapy antineoplastic drugs. Panax ginseng is a well-known medicinal herb and has a long history of medicinal use as a tonic to promote health. AIM: This work aimed to study the effect of ginseng on the liver damage induced by cisplatin in rat...

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Autores principales: Alrashed, Abdulaziz Abdulrahman, El-Kordy, Eman Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585476/
https://www.ncbi.nlm.nih.gov/pubmed/31293890
http://dx.doi.org/10.4103/JMAU.JMAU_4_19
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author Alrashed, Abdulaziz Abdulrahman
El-Kordy, Eman Ali
author_facet Alrashed, Abdulaziz Abdulrahman
El-Kordy, Eman Ali
author_sort Alrashed, Abdulaziz Abdulrahman
collection PubMed
description BACKGROUND: Cisplatin is one of the most effective chemotherapy antineoplastic drugs. Panax ginseng is a well-known medicinal herb and has a long history of medicinal use as a tonic to promote health. AIM: This work aimed to study the effect of ginseng on the liver damage induced by cisplatin in rats. It included biochemical and histological investigations. MATERIALS AND METHODS: Twenty adult rats were divided into four equal groups. Group I served as control. Group II received ginseng orally (100 mg/kg/day) for 4 weeks. Group III animals were injected intraperitoneally with cisplatin in three equal doses (each 3.3 mg/kg) daily for 3 consecutive days. Group IV animals received ginseng together with cisplatin by the same previously mentioned methods and doses. Rats were sacrificed after 4 weeks, and blood samples and liver tissues were collected for biochemical and histological examinations. RESULTS: Cisplatin-induced liver damage manifested biochemically by an increase in serum alanine aminotransferase and aspartate aminotransferase. Histologically, hepatocytes appeared with vacuolated cytoplasm and small dark-stained nuclei with dilatation of blood sinusoids as well as marked accumulation of collagen fibers around enlarged portal tracts. Administration of ginseng together with cisplatin improved the hepatic dysfunctions and damage caused by cisplatin. CONCLUSION: Ginseng has a protective role in the amelioration of cisplatin-induced hepatotoxicity.
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spelling pubmed-65854762019-07-10 Possible Protective Role of Panax Ginseng on Cisplatin-Induced Hepatotoxicity in Adult Male Albino Rats (Biochemical and Histological Study) Alrashed, Abdulaziz Abdulrahman El-Kordy, Eman Ali J Microsc Ultrastruct Original Article BACKGROUND: Cisplatin is one of the most effective chemotherapy antineoplastic drugs. Panax ginseng is a well-known medicinal herb and has a long history of medicinal use as a tonic to promote health. AIM: This work aimed to study the effect of ginseng on the liver damage induced by cisplatin in rats. It included biochemical and histological investigations. MATERIALS AND METHODS: Twenty adult rats were divided into four equal groups. Group I served as control. Group II received ginseng orally (100 mg/kg/day) for 4 weeks. Group III animals were injected intraperitoneally with cisplatin in three equal doses (each 3.3 mg/kg) daily for 3 consecutive days. Group IV animals received ginseng together with cisplatin by the same previously mentioned methods and doses. Rats were sacrificed after 4 weeks, and blood samples and liver tissues were collected for biochemical and histological examinations. RESULTS: Cisplatin-induced liver damage manifested biochemically by an increase in serum alanine aminotransferase and aspartate aminotransferase. Histologically, hepatocytes appeared with vacuolated cytoplasm and small dark-stained nuclei with dilatation of blood sinusoids as well as marked accumulation of collagen fibers around enlarged portal tracts. Administration of ginseng together with cisplatin improved the hepatic dysfunctions and damage caused by cisplatin. CONCLUSION: Ginseng has a protective role in the amelioration of cisplatin-induced hepatotoxicity. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6585476/ /pubmed/31293890 http://dx.doi.org/10.4103/JMAU.JMAU_4_19 Text en Copyright: © 2019 Journal of Microscopy and Ultrastructure http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Alrashed, Abdulaziz Abdulrahman
El-Kordy, Eman Ali
Possible Protective Role of Panax Ginseng on Cisplatin-Induced Hepatotoxicity in Adult Male Albino Rats (Biochemical and Histological Study)
title Possible Protective Role of Panax Ginseng on Cisplatin-Induced Hepatotoxicity in Adult Male Albino Rats (Biochemical and Histological Study)
title_full Possible Protective Role of Panax Ginseng on Cisplatin-Induced Hepatotoxicity in Adult Male Albino Rats (Biochemical and Histological Study)
title_fullStr Possible Protective Role of Panax Ginseng on Cisplatin-Induced Hepatotoxicity in Adult Male Albino Rats (Biochemical and Histological Study)
title_full_unstemmed Possible Protective Role of Panax Ginseng on Cisplatin-Induced Hepatotoxicity in Adult Male Albino Rats (Biochemical and Histological Study)
title_short Possible Protective Role of Panax Ginseng on Cisplatin-Induced Hepatotoxicity in Adult Male Albino Rats (Biochemical and Histological Study)
title_sort possible protective role of panax ginseng on cisplatin-induced hepatotoxicity in adult male albino rats (biochemical and histological study)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585476/
https://www.ncbi.nlm.nih.gov/pubmed/31293890
http://dx.doi.org/10.4103/JMAU.JMAU_4_19
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