Cargando…

Genome-Wide Mutagenesis Links Multiple Metabolic Pathways with Actinorhodin Production in Streptomyces coelicolor

Streptomyces species are important antibiotic-producing organisms that tightly regulate their antibiotic production. Actinorhodin is a typical antibiotic produced by the model actinomycete Streptomyces coelicolor. To discover the regulators of actinorhodin production, we constructed a library of 50,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Zhong, Li, Yuanyuan, Wang, Yemin, Deng, Zixin, Tao, Meifeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Genetics and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585502/ https://www.ncbi.nlm.nih.gov/pubmed/30709825 http://dx.doi.org/10.1128/AEM.03005-18

Ejemplares similares

Myxococcus xanthus induces actinorhodin overproduction and aerial mycelium formation by Streptomyces coelicolor
por: Pérez, Juana, et al.
Publicado: (2011)

A Two-Step Mechanism for the Activation of Actinorhodin Export and Resistance in Streptomyces coelicolor
por: Xu, Ye, et al.
Publicado: (2012)

Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2)
por: Uguru, Gabriel C., et al.
Publicado: (2013)

Multi-Omics Analysis of the Effect of cAMP on Actinorhodin Production in Streptomyces coelicolor
por: Nitta, Katsuaki, et al.
Publicado: (2020)

Synthetic Promoter Library for Modulation of Actinorhodin Production in Streptomyces coelicolor A3(2)
por: Sohoni, Sujata Vijay, et al.
Publicado: (2014)

Mechanism of CuO nano-particles on stimulating production of actinorhodin in Streptomyces coelicolor by transcriptional analysis
por: Liu, Xiaomei, et al.
Publicado: (2019)

The SCO1731 methyltransferase modulates actinorhodin production and morphological differentiation of Streptomyces coelicolor A3(2)
por: Pisciotta, Annalisa, et al.
Publicado: (2018)

Sulfane sulfur‐activated actinorhodin production and sporulation is maintained by a natural gene circuit in Streptomyces coelicolor
por: Lu, Ting, et al.
Publicado: (2020)

Evidence of a role for CutRS and actinorhodin in the secretion stress response in Streptomyces coelicolor M145
por: McLean, Thomas C., et al.
Publicado: (2023)

LAL Regulators SCO0877 and SCO7173 as Pleiotropic Modulators of Phosphate Starvation Response and Actinorhodin Biosynthesis in Streptomyces coelicolor
por: Guerra, Susana M., et al.
Publicado: (2012)

Sulfane Sulfur Posttranslationally Modifies the Global Regulator AdpA to Influence Actinorhodin Production and Morphological Differentiation of Streptomyces coelicolor
por: Lu, Ting, et al.
Publicado: (2022)

Target genes and structure of the direct repeats in the DNA-binding sequences of the response regulator PhoP in Streptomyces coelicolor
por: Sola-Landa, Alberto, et al.
Publicado: (2008)

In vivo DNase I sensitivity of the Streptomyces coelicolor chromosome correlates with gene expression: implications for bacterial chromosome structure
por: McArthur, Michael, et al.
Publicado: (2006)

Competition between the GlnR and PhoP regulators for the glnA and amtB promoters in Streptomyces coelicolor
por: Sola-Landa, Alberto, et al.
Publicado: (2013)

The Streptomyces coelicolor Small ORF trpM Stimulates Growth and Morphological Development and Exerts Opposite Effects on Actinorhodin and Calcium-Dependent Antibiotic Production
por: Vassallo, Alberto, et al.
Publicado: (2020)

Deletion of MtrA Inhibits Cellular Development of Streptomyces coelicolor and Alters Expression of Developmental Regulatory Genes
por: Zhang, Peipei, et al.
Publicado: (2017)

Dissection of 3D chromosome organization in Streptomyces coelicolor A3(2) leads to biosynthetic gene cluster overexpression
por: Deng, Liang, et al.
Publicado: (2023)

Carbon-Flux Distribution within Streptomyces coelicolor Metabolism: A Comparison between the Actinorhodin-Producing Strain M145 and Its Non-Producing Derivative M1146
por: Coze, Fabien, et al.
Publicado: (2013)

Structure–function relationships of two paralogous single-stranded DNA-binding proteins from Streptomyces coelicolor: implication of SsbB in chromosome segregation during sporulation
por: Paradzik, Tina, et al.
Publicado: (2013)

Genome-wide inference of regulatory networks in Streptomyces coelicolor
por: Castro-Melchor, Marlene, et al.
Publicado: (2010)

Phosphate control over nitrogen metabolism in Streptomyces coelicolor: direct and indirect negative control of glnR, glnA, glnII and amtB expression by the response regulator PhoP
por: Rodríguez-García, Antonio, et al.
Publicado: (2009)

Multiplying the heterologous production of spinosad through tandem amplification of its biosynthetic gene cluster in Streptomyces coelicolor
por: Li, Hong, et al.
Publicado: (2021)

The dynamic architecture of the metabolic switch in Streptomyces coelicolor
por: Nieselt, Kay, et al.
Publicado: (2010)

Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor
por: Alam, Mohammad T, et al.
Publicado: (2010)

The Streptomyces filipinensis Gamma-Butyrolactone System Reveals Novel Clues for Understanding the Control of Secondary Metabolism
por: Barreales, Eva G., et al.
Publicado: (2020)

OBSERVATIONS ON THE CHROMATINIC BODIES OF Streptomyces coelicolor
por: Hopwood, David A., et al.
Publicado: (1960)

Proteomic survey of the Streptomyces coelicolor nucleoid
por: Bradshaw, Elizabeth, et al.
Publicado: (2013)

Cosmid based mutagenesis causes genetic instability in Streptomyces coelicolor, as shown by targeting of the lipoprotein signal peptidase gene
por: Munnoch, John T., et al.
Publicado: (2016)

Alanine-scanning mutagenesis of protein mannosyl-transferase from Streptomyces coelicolor reveals strong activity-stability correlation
por: Holman, Nathaniel D. M., et al.
Publicado: (2021)

Genome Integration and Excision by a New Streptomyces Bacteriophage, ϕJoe
por: Fogg, Paul C. M., et al.
Publicado: (2017)

Identification and Heterologous Expression of the Chaxamycin Biosynthesis Gene Cluster from Streptomyces leeuwenhoekii
por: Castro, Jean Franco, et al.
Publicado: (2015)

Promoter Engineering Reveals the Importance of Heptameric Direct Repeats for DNA Binding by Streptomyces Antibiotic Regulatory Protein–Large ATP-Binding Regulator of the LuxR Family (SARP-LAL) Regulators in Streptomyces natalensis
por: Barreales, Eva G., et al.
Publicado: (2018)

Biosynthesis of Aurodox, a Type III Secretion System Inhibitor from Streptomyces goldiniensis
por: McHugh, Rebecca E., et al.
Publicado: (2022)

Biochemical studies of the multicopper oxidase (small laccase) from Streptomyces coelicolor using bioactive phytochemicals and site-directed mutagenesis
por: Sherif, Mohammed, et al.
Publicado: (2013)

Effects of carbon ion beam-induced mutagenesis for the screening of RED production-deficient mutants of Streptomyces coelicolor JCM4020
por: Yanagisawa, Masaomi, et al.
Publicado: (2022)

Analysis of gene expression in operons of Streptomyces coelicolor
por: Laing, Emma, et al.
Publicado: (2006)

A Membranous Component of the Cytoplasm in Streptomyces coelicolor
por: Glauert, Audrey M., et al.
Publicado: (1959)

Small non-coding RNAs in Streptomyces coelicolor
por: Swiercz, Julia P., et al.
Publicado: (2008)

Streptomyces coelicolor Vesicles: Many Molecules To Be Delivered
por: Faddetta, Teresa, et al.
Publicado: (2022)

Prodiginines Postpone the Onset of Sporulation in Streptomyces coelicolor
por: Tenconi, Elodie, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1v34gmnieku6tnr0tlsjp9a54v