Physiologically Based Pharmacokinetic Modeling for Olaparib Dosing Recommendations: Bridging Formulations, Drug Interactions, and Patient Populations

We report physiologically based pharmacokinetic‐modeling analyses to determine olaparib (tablet or capsule) drug–drug interactions (DDIs). Verified DDI simulations provided dose recommendations for olaparib coadministration with clinically relevant CYP3A4 modulators to eliminate potential risk to pa...

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Detalles Bibliográficos
Autores principales: Pilla Reddy, Venkatesh, Bui, Khanh, Scarfe, Graeme, Zhou, Diansong, Learoyd, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585620/
https://www.ncbi.nlm.nih.gov/pubmed/29717476
http://dx.doi.org/10.1002/cpt.1103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585620/
https://www.ncbi.nlm.nih.gov/pubmed/29717476
http://dx.doi.org/10.1002/cpt.1103

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