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Clopidogrel Increases Dasabuvir Exposure With or Without Ritonavir, and Ritonavir Inhibits the Bioactivation of Clopidogrel

Dasabuvir is mainly metabolized by cytochrome P450 (CYP) 2C8 and is predominantly used in a regimen containing ritonavir. Ritonavir and clopidogrel are inhibitors of CYP3A4 and CYP2C8, respectively. In a randomized, crossover study in 12 healthy subjects, we examined the impact of clinical doses of...

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Detalles Bibliográficos
Autores principales:	Itkonen, Matti K., Tornio, Aleksi, Lapatto‐Reiniluoto, Outi, Neuvonen, Mikko, Neuvonen, Pertti J., Niemi, Mikko, Backman, Janne T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585621/ https://www.ncbi.nlm.nih.gov/pubmed/29696643 http://dx.doi.org/10.1002/cpt.1099

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