Genomic Variation and Pharmacokinetics in Old Age: A Quantitative Review of Age‐ vs. Genotype‐Related Differences

Older persons may particularly benefit from pharmacogenetic diagnostics, but there is little clinical evidence on that question. We quantitatively analyzed the effects of age and genotype in drugs with consensus on a therapeutically relevant impact of a genotype. Assuming additive effects of age and...

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Detalles Bibliográficos
Autores principales: Dücker, Christof M., Brockmöller, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585622/
https://www.ncbi.nlm.nih.gov/pubmed/29498032
http://dx.doi.org/10.1002/cpt.1057
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author Dücker, Christof M.
Brockmöller, Jürgen
author_facet Dücker, Christof M.
Brockmöller, Jürgen
author_sort Dücker, Christof M.
collection PubMed
description Older persons may particularly benefit from pharmacogenetic diagnostics, but there is little clinical evidence on that question. We quantitatively analyzed the effects of age and genotype in drugs with consensus on a therapeutically relevant impact of a genotype. Assuming additive effects of age and genotype, drugs may be classified in groups with different priorities to consider either age, or genotype, or both, in therapy. Particularly interesting were those studies specifically analyzing the age‐by‐genotype interaction.
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spelling pubmed-65856222019-06-27 Genomic Variation and Pharmacokinetics in Old Age: A Quantitative Review of Age‐ vs. Genotype‐Related Differences Dücker, Christof M. Brockmöller, Jürgen Clin Pharmacol Ther Reviews Older persons may particularly benefit from pharmacogenetic diagnostics, but there is little clinical evidence on that question. We quantitatively analyzed the effects of age and genotype in drugs with consensus on a therapeutically relevant impact of a genotype. Assuming additive effects of age and genotype, drugs may be classified in groups with different priorities to consider either age, or genotype, or both, in therapy. Particularly interesting were those studies specifically analyzing the age‐by‐genotype interaction. John Wiley and Sons Inc. 2018-04-02 2019-03 /pmc/articles/PMC6585622/ /pubmed/29498032 http://dx.doi.org/10.1002/cpt.1057 Text en © 2018 The Authors Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Reviews
Dücker, Christof M.
Brockmöller, Jürgen
Genomic Variation and Pharmacokinetics in Old Age: A Quantitative Review of Age‐ vs. Genotype‐Related Differences
title Genomic Variation and Pharmacokinetics in Old Age: A Quantitative Review of Age‐ vs. Genotype‐Related Differences
title_full Genomic Variation and Pharmacokinetics in Old Age: A Quantitative Review of Age‐ vs. Genotype‐Related Differences
title_fullStr Genomic Variation and Pharmacokinetics in Old Age: A Quantitative Review of Age‐ vs. Genotype‐Related Differences
title_full_unstemmed Genomic Variation and Pharmacokinetics in Old Age: A Quantitative Review of Age‐ vs. Genotype‐Related Differences
title_short Genomic Variation and Pharmacokinetics in Old Age: A Quantitative Review of Age‐ vs. Genotype‐Related Differences
title_sort genomic variation and pharmacokinetics in old age: a quantitative review of age‐ vs. genotype‐related differences
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585622/
https://www.ncbi.nlm.nih.gov/pubmed/29498032
http://dx.doi.org/10.1002/cpt.1057
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