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Posttransplant muscle mass measured by urinary creatinine excretion rate predicts long‐term outcomes after liver transplantation
Long‐term survival in orthotopic liver transplant (OLT) recipients remains impaired because of many contributing factors, including a low pretransplant muscle mass (or sarcopenia). However, influence of posttransplant muscle mass on survival is currently unknown. We hypothesized that posttransplant...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585633/ https://www.ncbi.nlm.nih.gov/pubmed/29745020 http://dx.doi.org/10.1111/ajt.14926 |
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author | Stam, Suzanne P. Osté, Maryse C. J. Eisenga, Michele F. Blokzijl, Hans van den Berg, Aad P. Bakker, Stephan J. L. de Meijer, Vincent E. |
author_facet | Stam, Suzanne P. Osté, Maryse C. J. Eisenga, Michele F. Blokzijl, Hans van den Berg, Aad P. Bakker, Stephan J. L. de Meijer, Vincent E. |
author_sort | Stam, Suzanne P. |
collection | PubMed |
description | Long‐term survival in orthotopic liver transplant (OLT) recipients remains impaired because of many contributing factors, including a low pretransplant muscle mass (or sarcopenia). However, influence of posttransplant muscle mass on survival is currently unknown. We hypothesized that posttransplant urinary creatinine excretion rate (CER), an established noninvasive marker of total body muscle mass, is associated with long‐term survival after OLT. In a single‐center cohort study of 382 adult OLT recipients, mean ± standard deviation CER at 1 year posttransplantation was 13.3 ± 3.7 mmol/24 h in men and 9.4 ± 2.6 mmol/24 h in women. During median follow‐up for 9.8 y (interquartile range 6.4‐15.0 y), 104 (27.2%) OLT recipients died and 44 (11.5%) developed graft failure. In Cox regression analyses, as continuous variable, low CER was associated with increased risk for mortality (HR = 0.43, 95% CI: 0.26‐0.71, P = .001) and graft failure (HR = 0.42, 95% CI: 0.20‐0.90, P = .03), independent of age, sex, and body surface area. Similarly, OLT recipients in the lowest tertile had an increased risk for mortality (HR = 2.69; 95% CI: 1.47‐4.91, P = .001) and graft failure (HR = 2.77, 95% CI: 1.04‐7.39, P = .04), compared to OLT recipients in the highest tertile. We conclude that 1 year posttransplant low total body muscle mass is associated with long‐term risk of mortality and graft failure in OLT recipients. |
format | Online Article Text |
id | pubmed-6585633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65856332019-06-27 Posttransplant muscle mass measured by urinary creatinine excretion rate predicts long‐term outcomes after liver transplantation Stam, Suzanne P. Osté, Maryse C. J. Eisenga, Michele F. Blokzijl, Hans van den Berg, Aad P. Bakker, Stephan J. L. de Meijer, Vincent E. Am J Transplant ORIGINAL ARTICLES Long‐term survival in orthotopic liver transplant (OLT) recipients remains impaired because of many contributing factors, including a low pretransplant muscle mass (or sarcopenia). However, influence of posttransplant muscle mass on survival is currently unknown. We hypothesized that posttransplant urinary creatinine excretion rate (CER), an established noninvasive marker of total body muscle mass, is associated with long‐term survival after OLT. In a single‐center cohort study of 382 adult OLT recipients, mean ± standard deviation CER at 1 year posttransplantation was 13.3 ± 3.7 mmol/24 h in men and 9.4 ± 2.6 mmol/24 h in women. During median follow‐up for 9.8 y (interquartile range 6.4‐15.0 y), 104 (27.2%) OLT recipients died and 44 (11.5%) developed graft failure. In Cox regression analyses, as continuous variable, low CER was associated with increased risk for mortality (HR = 0.43, 95% CI: 0.26‐0.71, P = .001) and graft failure (HR = 0.42, 95% CI: 0.20‐0.90, P = .03), independent of age, sex, and body surface area. Similarly, OLT recipients in the lowest tertile had an increased risk for mortality (HR = 2.69; 95% CI: 1.47‐4.91, P = .001) and graft failure (HR = 2.77, 95% CI: 1.04‐7.39, P = .04), compared to OLT recipients in the highest tertile. We conclude that 1 year posttransplant low total body muscle mass is associated with long‐term risk of mortality and graft failure in OLT recipients. John Wiley and Sons Inc. 2018-06-03 2019-02 /pmc/articles/PMC6585633/ /pubmed/29745020 http://dx.doi.org/10.1111/ajt.14926 Text en © 2018 The Authors. American Journal of Transplantation published by Wiley Periodicals, Inc. on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | ORIGINAL ARTICLES Stam, Suzanne P. Osté, Maryse C. J. Eisenga, Michele F. Blokzijl, Hans van den Berg, Aad P. Bakker, Stephan J. L. de Meijer, Vincent E. Posttransplant muscle mass measured by urinary creatinine excretion rate predicts long‐term outcomes after liver transplantation |
title | Posttransplant muscle mass measured by urinary creatinine excretion rate predicts long‐term outcomes after liver transplantation |
title_full | Posttransplant muscle mass measured by urinary creatinine excretion rate predicts long‐term outcomes after liver transplantation |
title_fullStr | Posttransplant muscle mass measured by urinary creatinine excretion rate predicts long‐term outcomes after liver transplantation |
title_full_unstemmed | Posttransplant muscle mass measured by urinary creatinine excretion rate predicts long‐term outcomes after liver transplantation |
title_short | Posttransplant muscle mass measured by urinary creatinine excretion rate predicts long‐term outcomes after liver transplantation |
title_sort | posttransplant muscle mass measured by urinary creatinine excretion rate predicts long‐term outcomes after liver transplantation |
topic | ORIGINAL ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585633/ https://www.ncbi.nlm.nih.gov/pubmed/29745020 http://dx.doi.org/10.1111/ajt.14926 |
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