Cargando…
Retention rates of adalimumab, etanercept, and infliximab as first‐ or second‐line biotherapies for spondyloarthritis patients in daily practice in Auvergne (France)
OBJECTIVE: To compare, in real‐life settings, the retention rates of initial anti‐tumor‐necrosis factor (TNF) treatments (etanercept [ETN], adalimumab [ADA] and infliximab [IFX]) used as first‐line biotherapy for axial spondyloarthritis (axSpA), and evaluate treatment switches to another anti‐TNF in...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585683/ https://www.ncbi.nlm.nih.gov/pubmed/30168265 http://dx.doi.org/10.1111/1756-185X.13375 |
_version_ | 1783428749685948416 |
---|---|
author | Soubrier, Martin Pereira, Bruno Fan, Angelique Frayssac, Thomas Couderc, Marion Malochet‐Guinamand, Sandrine Mathieu, Sylvain Tatar, Zuzana Tournadre, Anne Dubost, Jean‐Jacques |
author_facet | Soubrier, Martin Pereira, Bruno Fan, Angelique Frayssac, Thomas Couderc, Marion Malochet‐Guinamand, Sandrine Mathieu, Sylvain Tatar, Zuzana Tournadre, Anne Dubost, Jean‐Jacques |
author_sort | Soubrier, Martin |
collection | PubMed |
description | OBJECTIVE: To compare, in real‐life settings, the retention rates of initial anti‐tumor‐necrosis factor (TNF) treatments (etanercept [ETN], adalimumab [ADA] and infliximab [IFX]) used as first‐line biotherapy for axial spondyloarthritis (axSpA), and evaluate treatment switches to another anti‐TNF inhibitor in the event of treatment failure. METHODS: We analyzed the medical records of all SpA patients (Assessment in Ankylosing Spondylitis International Working Group axial criteria) treated with ETN, IFX or ADA between 2001 and February 2015. Drug retention rates were calculated using the Kaplan‐Meier method and compared by means of the Cox extended model. Sub‐analyses were performed according to discontinuation reasons. RESULTS: Of the 249 SpA patients analyzed (135 radiographic cases, 114 non‐radiographic), 102 received ETN, 62 ADA, and 85 IFX. In total, 103 discontinued treatment. The retention rates of IFX, ADA and ETN were 67%, 59% and 56% after 3 years; 62%, 42% and 47% after 5 years; 55%, 42% and 24% after 8 years; 53%, 42% and 12% after 10 years, respectively. In multivariate analyses, the predictive factors for retention were: low BASDAI score (hazard ratio [HR]: 1.02 [1.01‐1.04]), high C‐reactive protein levels (HR: 0.98 [0.97‐0.99]), concomitant disease‐modifying therapy (HR: 0.4 [0.21‐0.75]), and radiographic SpA (HR: 1.5 [1.0‐2.52]). In total, 61 patients switched to another anti‐TNF therapy. No difference was observed among the three anti‐TNF therapies regarding median retention duration, although the retention rate proved higher for treatment switches from one monoclonal antibody to another. CONCLUSION: The retention rate in SpA patients proved high, with retention for IFX superior to that of ETN. |
format | Online Article Text |
id | pubmed-6585683 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65856832019-06-27 Retention rates of adalimumab, etanercept, and infliximab as first‐ or second‐line biotherapies for spondyloarthritis patients in daily practice in Auvergne (France) Soubrier, Martin Pereira, Bruno Fan, Angelique Frayssac, Thomas Couderc, Marion Malochet‐Guinamand, Sandrine Mathieu, Sylvain Tatar, Zuzana Tournadre, Anne Dubost, Jean‐Jacques Int J Rheum Dis Original Articles OBJECTIVE: To compare, in real‐life settings, the retention rates of initial anti‐tumor‐necrosis factor (TNF) treatments (etanercept [ETN], adalimumab [ADA] and infliximab [IFX]) used as first‐line biotherapy for axial spondyloarthritis (axSpA), and evaluate treatment switches to another anti‐TNF inhibitor in the event of treatment failure. METHODS: We analyzed the medical records of all SpA patients (Assessment in Ankylosing Spondylitis International Working Group axial criteria) treated with ETN, IFX or ADA between 2001 and February 2015. Drug retention rates were calculated using the Kaplan‐Meier method and compared by means of the Cox extended model. Sub‐analyses were performed according to discontinuation reasons. RESULTS: Of the 249 SpA patients analyzed (135 radiographic cases, 114 non‐radiographic), 102 received ETN, 62 ADA, and 85 IFX. In total, 103 discontinued treatment. The retention rates of IFX, ADA and ETN were 67%, 59% and 56% after 3 years; 62%, 42% and 47% after 5 years; 55%, 42% and 24% after 8 years; 53%, 42% and 12% after 10 years, respectively. In multivariate analyses, the predictive factors for retention were: low BASDAI score (hazard ratio [HR]: 1.02 [1.01‐1.04]), high C‐reactive protein levels (HR: 0.98 [0.97‐0.99]), concomitant disease‐modifying therapy (HR: 0.4 [0.21‐0.75]), and radiographic SpA (HR: 1.5 [1.0‐2.52]). In total, 61 patients switched to another anti‐TNF therapy. No difference was observed among the three anti‐TNF therapies regarding median retention duration, although the retention rate proved higher for treatment switches from one monoclonal antibody to another. CONCLUSION: The retention rate in SpA patients proved high, with retention for IFX superior to that of ETN. John Wiley and Sons Inc. 2018-08-30 2018-11 /pmc/articles/PMC6585683/ /pubmed/30168265 http://dx.doi.org/10.1111/1756-185X.13375 Text en © 2018 The Authors. International Journal of Rheumatic Diseases published by Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Soubrier, Martin Pereira, Bruno Fan, Angelique Frayssac, Thomas Couderc, Marion Malochet‐Guinamand, Sandrine Mathieu, Sylvain Tatar, Zuzana Tournadre, Anne Dubost, Jean‐Jacques Retention rates of adalimumab, etanercept, and infliximab as first‐ or second‐line biotherapies for spondyloarthritis patients in daily practice in Auvergne (France) |
title | Retention rates of adalimumab, etanercept, and infliximab as first‐ or second‐line biotherapies for spondyloarthritis patients in daily practice in Auvergne (France) |
title_full | Retention rates of adalimumab, etanercept, and infliximab as first‐ or second‐line biotherapies for spondyloarthritis patients in daily practice in Auvergne (France) |
title_fullStr | Retention rates of adalimumab, etanercept, and infliximab as first‐ or second‐line biotherapies for spondyloarthritis patients in daily practice in Auvergne (France) |
title_full_unstemmed | Retention rates of adalimumab, etanercept, and infliximab as first‐ or second‐line biotherapies for spondyloarthritis patients in daily practice in Auvergne (France) |
title_short | Retention rates of adalimumab, etanercept, and infliximab as first‐ or second‐line biotherapies for spondyloarthritis patients in daily practice in Auvergne (France) |
title_sort | retention rates of adalimumab, etanercept, and infliximab as first‐ or second‐line biotherapies for spondyloarthritis patients in daily practice in auvergne (france) |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585683/ https://www.ncbi.nlm.nih.gov/pubmed/30168265 http://dx.doi.org/10.1111/1756-185X.13375 |
work_keys_str_mv | AT soubriermartin retentionratesofadalimumabetanerceptandinfliximabasfirstorsecondlinebiotherapiesforspondyloarthritispatientsindailypracticeinauvergnefrance AT pereirabruno retentionratesofadalimumabetanerceptandinfliximabasfirstorsecondlinebiotherapiesforspondyloarthritispatientsindailypracticeinauvergnefrance AT fanangelique retentionratesofadalimumabetanerceptandinfliximabasfirstorsecondlinebiotherapiesforspondyloarthritispatientsindailypracticeinauvergnefrance AT frayssacthomas retentionratesofadalimumabetanerceptandinfliximabasfirstorsecondlinebiotherapiesforspondyloarthritispatientsindailypracticeinauvergnefrance AT coudercmarion retentionratesofadalimumabetanerceptandinfliximabasfirstorsecondlinebiotherapiesforspondyloarthritispatientsindailypracticeinauvergnefrance AT malochetguinamandsandrine retentionratesofadalimumabetanerceptandinfliximabasfirstorsecondlinebiotherapiesforspondyloarthritispatientsindailypracticeinauvergnefrance AT mathieusylvain retentionratesofadalimumabetanerceptandinfliximabasfirstorsecondlinebiotherapiesforspondyloarthritispatientsindailypracticeinauvergnefrance AT tatarzuzana retentionratesofadalimumabetanerceptandinfliximabasfirstorsecondlinebiotherapiesforspondyloarthritispatientsindailypracticeinauvergnefrance AT tournadreanne retentionratesofadalimumabetanerceptandinfliximabasfirstorsecondlinebiotherapiesforspondyloarthritispatientsindailypracticeinauvergnefrance AT dubostjeanjacques retentionratesofadalimumabetanerceptandinfliximabasfirstorsecondlinebiotherapiesforspondyloarthritispatientsindailypracticeinauvergnefrance |