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Tramadol Hydrochloride at Steady State Lacks Clinically Relevant QTc Interval Increases in Healthy Adults

We evaluated the effects of therapeutic and supratherapeutic doses of tramadol hydrochloride on the corrected QT (QTc) interval in healthy adults (aged 18‐55 years) in a randomized, phase I, double‐blind, placebo‐ and positive‐controlled, multiple‐dose, 4‐way crossover study. Participants were rando...

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Detalles Bibliográficos
Autores principales:	Massarella, Joseph, Ariyawansa, Jay, Natarajan, Jaya, Francke, Stephan, Murtaugh, Thomas, DeLemos, Byron, Vaughan, Subusola, Fonseca, Sergio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585761/ https://www.ncbi.nlm.nih.gov/pubmed/29775246 http://dx.doi.org/10.1002/cpdd.473

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