Cargando…

Acute and chronic modulation of striatal endocannabinoid‐mediated plasticity by nicotine

The endocannabinoid (eCB) system modulates several phenomena related to addictive behaviors, and drug‐induced changes in eCB signaling have been postulated to be important mediators of physiological and pathological reward‐related synaptic plasticity. Here, we studied eCB‐mediated long‐term depressi...

Descripción completa

Detalles Bibliográficos
Autores principales: Adermark, Louise, Morud, Julia, Lotfi, Amir, Ericson, Mia, Söderpalm, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585825/
https://www.ncbi.nlm.nih.gov/pubmed/29292565
http://dx.doi.org/10.1111/adb.12598
_version_ 1783428782766424064
author Adermark, Louise
Morud, Julia
Lotfi, Amir
Ericson, Mia
Söderpalm, Bo
author_facet Adermark, Louise
Morud, Julia
Lotfi, Amir
Ericson, Mia
Söderpalm, Bo
author_sort Adermark, Louise
collection PubMed
description The endocannabinoid (eCB) system modulates several phenomena related to addictive behaviors, and drug‐induced changes in eCB signaling have been postulated to be important mediators of physiological and pathological reward‐related synaptic plasticity. Here, we studied eCB‐mediated long‐term depression (eCB‐LTD) in the dorsolateral striatum, a brain region critical for acquisition of habitual and automatic behavior. We report that nicotine differentially affects ex vivo eCB signaling depending on previous exposure in vivo. In the nicotine‐naïve brain, nicotine facilitates eCB‐signaling and LTD, whereas tolerance develops to this facilitating effect after subchronic exposure in vivo. In the end, a progressive impairment of eCB‐induced LTD is established after protracted withdrawal from nicotine. Endocannabinoid‐LTD is reinstated 6 months after the last drug injection, but a brief period of nicotine re‐exposure is sufficient to yet again impair eCB‐signaling. LTD induced by the cannabinoid 1 receptor agonist WIN55,212‐2 is not affected, suggesting that nicotine modulates eCB production or release. Nicotine‐induced facilitation of eCB‐LTD is occluded by the dopamine D2 receptor agonist quinpirole, and by the muscarinic acetylcholine receptor antagonist scopolamine. In addition, the same compounds restore eCB‐LTD during protracted withdrawal. Nicotine may thus modulate eCB‐signaling by affecting dopaminergic and cholinergic neurotransmission in a long‐lasting manner. Overall, the data presented here suggest that nicotine facilitates eCB‐LTD in the initial phase, which putatively could promote neurophysiological and behavioral adaptations to the drug. Protracted withdrawal, however, impairs eCB‐LTD, which may influence or affect the ability to maintain cessation.
format Online
Article
Text
id pubmed-6585825
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-65858252019-06-27 Acute and chronic modulation of striatal endocannabinoid‐mediated plasticity by nicotine Adermark, Louise Morud, Julia Lotfi, Amir Ericson, Mia Söderpalm, Bo Addict Biol Preclinical Studies The endocannabinoid (eCB) system modulates several phenomena related to addictive behaviors, and drug‐induced changes in eCB signaling have been postulated to be important mediators of physiological and pathological reward‐related synaptic plasticity. Here, we studied eCB‐mediated long‐term depression (eCB‐LTD) in the dorsolateral striatum, a brain region critical for acquisition of habitual and automatic behavior. We report that nicotine differentially affects ex vivo eCB signaling depending on previous exposure in vivo. In the nicotine‐naïve brain, nicotine facilitates eCB‐signaling and LTD, whereas tolerance develops to this facilitating effect after subchronic exposure in vivo. In the end, a progressive impairment of eCB‐induced LTD is established after protracted withdrawal from nicotine. Endocannabinoid‐LTD is reinstated 6 months after the last drug injection, but a brief period of nicotine re‐exposure is sufficient to yet again impair eCB‐signaling. LTD induced by the cannabinoid 1 receptor agonist WIN55,212‐2 is not affected, suggesting that nicotine modulates eCB production or release. Nicotine‐induced facilitation of eCB‐LTD is occluded by the dopamine D2 receptor agonist quinpirole, and by the muscarinic acetylcholine receptor antagonist scopolamine. In addition, the same compounds restore eCB‐LTD during protracted withdrawal. Nicotine may thus modulate eCB‐signaling by affecting dopaminergic and cholinergic neurotransmission in a long‐lasting manner. Overall, the data presented here suggest that nicotine facilitates eCB‐LTD in the initial phase, which putatively could promote neurophysiological and behavioral adaptations to the drug. Protracted withdrawal, however, impairs eCB‐LTD, which may influence or affect the ability to maintain cessation. John Wiley and Sons Inc. 2018-01-02 2019-05 /pmc/articles/PMC6585825/ /pubmed/29292565 http://dx.doi.org/10.1111/adb.12598 Text en © 2018 The Authors.Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Preclinical Studies
Adermark, Louise
Morud, Julia
Lotfi, Amir
Ericson, Mia
Söderpalm, Bo
Acute and chronic modulation of striatal endocannabinoid‐mediated plasticity by nicotine
title Acute and chronic modulation of striatal endocannabinoid‐mediated plasticity by nicotine
title_full Acute and chronic modulation of striatal endocannabinoid‐mediated plasticity by nicotine
title_fullStr Acute and chronic modulation of striatal endocannabinoid‐mediated plasticity by nicotine
title_full_unstemmed Acute and chronic modulation of striatal endocannabinoid‐mediated plasticity by nicotine
title_short Acute and chronic modulation of striatal endocannabinoid‐mediated plasticity by nicotine
title_sort acute and chronic modulation of striatal endocannabinoid‐mediated plasticity by nicotine
topic Preclinical Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585825/
https://www.ncbi.nlm.nih.gov/pubmed/29292565
http://dx.doi.org/10.1111/adb.12598
work_keys_str_mv AT adermarklouise acuteandchronicmodulationofstriatalendocannabinoidmediatedplasticitybynicotine
AT morudjulia acuteandchronicmodulationofstriatalendocannabinoidmediatedplasticitybynicotine
AT lotfiamir acuteandchronicmodulationofstriatalendocannabinoidmediatedplasticitybynicotine
AT ericsonmia acuteandchronicmodulationofstriatalendocannabinoidmediatedplasticitybynicotine
AT soderpalmbo acuteandchronicmodulationofstriatalendocannabinoidmediatedplasticitybynicotine