Iron refractory iron deficiency anemia: a heterogeneous disease that is not always iron refractory

TMPRSS6 variants that affect protein function result in impaired matriptase‐2 function and consequently uninhibited hepcidin production, leading to iron refractory iron deficiency anemia (IRIDA). This disease is characterized by microcytic, hypochromic anemia and serum hepcidin values that are inapp...

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Detalles Bibliográficos
Autores principales: Donker, Albertine E., Schaap, Charlotte C.M., Novotny, Vera M. J., Smeets, Roel, Peters, Tessa M. A., van den Heuvel, Bert L. P., Raphael, Martine F., Rijneveld, Anita W., Appel, Inge M., Vlot, Andre J., Versluijs, A. Birgitta, van Gelder, Michel, Granzen, Bernd, Janssen, Mirian C.H., Rennings, Alexander J.M., van de Veerdonk, Frank L., Brons, Paul P.T., Bakkeren, Dirk L., Nijziel, Marten R., Vlasveld, L. Thom, Swinkels, Dorine W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
E‐ONLY Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586001/
https://www.ncbi.nlm.nih.gov/pubmed/27643674
http://dx.doi.org/10.1002/ajh.24561

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