Inhibiting homologous recombination decreases extrachromosomal amplification but has no effect on intrachromosomal amplification in methotrexate‐resistant colon cancer cells

Gene amplification, which involves the two major topographical structures double minutes (DMs) and homegeneously stained region (HSR), is a common mechanism of treatment resistance in cancer and is initiated by DNA double‐strand breaks. NHEJ, one of DSB repair pathways, is involved in gene amplifica...

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Detalles Bibliográficos
Autores principales: Cai, Mengdi, Zhang, Huishu, Hou, Liqing, Gao, Wei, Song, Ying, Cui, Xiaobo, Li, Chunxiang, Guan, Rongwei, Ma, Jinfa, Wang, Xu, Han, Yue, Lv, Yafan, Chen, Feng, Wang, Ping, Meng, Xiangning, Fu, Songbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Cancer Genetics and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586039/
https://www.ncbi.nlm.nih.gov/pubmed/30070702
http://dx.doi.org/10.1002/ijc.31781

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