Cargando…

Effects of a State‐ and Use‐Dependent Nav1.7 Channel Blocker on Ambulatory Blood Pressure: A Randomized, Controlled Crossover Study

Vixotrigine is a state‐ and use‐dependent Nav1.7 channel blocker being investigated for the treatment of neuropathic pain conditions. This randomized, double‐blind, placebo‐controlled crossover trial was designed to evaluate changes in blood pressure with the administration of vixotrigine using ambu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fong, Regan, Ballow, Charles H., Naik, Himanshu, Steiner, Deb, Palmer, Joanne, White, William B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586067/ https://www.ncbi.nlm.nih.gov/pubmed/30144099 http://dx.doi.org/10.1002/jcph.1298

Ejemplares similares

Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of Vixotrigine in Healthy Volunteers
por: Naik, Himanshu, et al.
Publicado: (2020)

Insights on β‐blockers for the treatment of hypertension: A survey of health care practitioners
por: Egan, Brent, et al.
Publicado: (2018)

Selective Closed-State Nav1.7 Blocker JZTX-34 Exhibits Analgesic Effects against Pain
por: Zeng, Xiongzhi, et al.
Publicado: (2018)

Impact of changes in pill appearance in the adherence to angiotensin receptor blockers and in the blood pressure levels: a retrospective cohort study
por: Lumbreras, B, et al.
Publicado: (2017)

Preferable effects of olmesartan/calcium channel blocker to olmesartan/diuretic on blood pressure variability in very elderly hypertension: COLM study subanalysis
por: Rakugi, Hiromi, et al.
Publicado: (2015)

Compound heterozygosity in sodium channel Nav1.7 in a family with hereditary erythermalgia
por: Samuels, Mark E, et al.
Publicado: (2008)

Inhibition of the Nav1.7 Channel in the Trigeminal Ganglion Relieves Pulpitis Inflammatory Pain
por: Kwon, Minjee, et al.
Publicado: (2021)

Heterologous functional expression of ascidian Nav1 channels and close relationship with the evolutionary ancestor of vertebrate Nav channels
por: Kawai, Takafumi, et al.
Publicado: (2021)

Left-Shifted Nav Channels in Injured Bilayer: Primary Targets for Neuroprotective Nav Antagonists?
por: Morris, Catherine E., et al.
Publicado: (2012)

Temperature dependence of erythromelalgia mutation L858F in sodium channel Nav1.7
por: Han, Chongyang, et al.
Publicado: (2007)

Sodium channel Nav1.7 in vascular myocytes, endothelium, and innervating axons in human skin
por: Rice, Frank L, et al.
Publicado: (2015)

Network topology of NaV1.7 mutations in sodium channel-related painful disorders
por: Kapetis, Dimos, et al.
Publicado: (2017)

General mechanism of spider toxin family I acting on sodium channel Nav1.7
por: Yuan, Fu-Chu, et al.
Publicado: (2022)

Identification of Navβ1 Residues Involved in the Modulation of the Sodium Channel Nav1.4
por: Islas, Angel A., et al.
Publicado: (2013)

Nav1.7 and Nav1.8: Diabetes-induced Changes in Primary Sensory Neurons in Rats
por: Lv, Jianlin, et al.
Publicado: (2016)

Effects of azilsartan medoxomil compared with olmesartan and valsartan on ambulatory and clinic blood pressure in patients with type 2 diabetes and prediabetes
por: White, William B., et al.
Publicado: (2016)

Open-Label Crossover Study of Primaquine and Dihydroartemisinin-Piperaquine Pharmacokinetics in Healthy Adult Thai Subjects
por: Hanboonkunupakarn, Borimas, et al.
Publicado: (2014)

Ambulatory blood pressure response to triple therapy with an angiotensin-receptor blocker (ARB), calcium-channel blocker (CCB), and HCTZ versus dual therapy with an ARB and HCTZ
por: Duprez, Daniel, et al.
Publicado: (2011)

Effects of acidosis on neuronal voltage-gated sodium channels: Nav1.1 and Nav1.3
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2018)

Bulleyaconitine A attenuates hyperexcitability of dorsal root ganglion neurons induced by spared nerve injury: The role of preferably blocking Nav1.7 and Nav1.3 channels
por: Xie, Man-Xiu, et al.
Publicado: (2018)

Nifedipine GITS/Candesartan Combination Therapy Lowers Blood Pressure Across Different Baseline Systolic and Diastolic Blood Pressure Categories: DISTINCT Study Subanalyses
por: Kjeldsen, Sverre E., et al.
Publicado: (2016)

Inhibition of androstenediol-dependent LNCaP tumour growth by 17α-ethynyl-5α-androstane-3α, 17β-diol (HE3235)
por: Trauger, R, et al.
Publicado: (2009)

β-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma
por: Pasquier, E, et al.
Publicado: (2013)

Synthesis and In Vivo Antiarrhythmic Activity Evaluation of Novel Scutellarein Analogues as Voltage-Gated Nav1.5 and Cav1.2 Channels Blockers
por: Yang, Wei, et al.
Publicado: (2023)

Phylogenetic relationships of the supercontig of sodium channel subunit I (NaV) in 17 species of Anopheles (Diptera: Culicidae)
por: Santos, Valéria Silva, et al.
Publicado: (2022)

Anti-tumour activity of afatinib, an irreversible ErbB family blocker, in human pancreatic tumour cells
por: Ioannou, N, et al.
Publicado: (2011)

β-Blocker treatment during pregnancy and adverse pregnancy outcomes: a nationwide population-based cohort study
por: Meidahl Petersen, Kasper, et al.
Publicado: (2012)

Kir2.1-Nav1.5 Channel Complexes Are Differently Regulated than Kir2.1 and Nav1.5 Channels Alone
por: Utrilla, Raquel G., et al.
Publicado: (2017)

Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction
por: Patel, Reesha R., et al.
Publicado: (2015)

Phosphorylation of a chronic pain mutation in the voltage-gated sodium channel Nav1.7 increases voltage sensitivity
por: Kerth, Clara M., et al.
Publicado: (2020)

The influence of Nav1.9 channels on intestinal hyperpathia and dysmotility
por: Zhao, Chenyu, et al.
Publicado: (2023)

Brevetoxin versus Brevenal Modulation of Human Nav1 Channels
por: Finol-Urdaneta, Rocio K., et al.
Publicado: (2023)

Blood pressure‐lowering effects of sulodexide depend on albuminuria severity: post hoc analysis of the sulodexide microalbuminuria and macroalbuminuria studies
por: Olde Engberink, Rik H. G., et al.
Publicado: (2016)

Lidocaine reduces pain behaviors by inhibiting the expression of Nav1.7 and Nav1.8 and diminishing sympathetic sprouting in SNI rats
por: Li, Xiaoxiao, et al.
Publicado: (2022)

Pain without Nociceptors? Nav1.7-Independent Pain Mechanisms
por: Minett, Michael S., et al.
Publicado: (2014)

Electroacupuncture Reduces Carrageenan- and CFA-Induced Inflammatory Pain Accompanied by Changing the Expression of Nav1.7 and Nav1.8, rather than Nav1.9, in Mice Dorsal Root Ganglia
por: Huang, Chun-Ping, et al.
Publicado: (2013)

Correlation of Nav1.8 and Nav1.9 sodium channel expression with neuropathic pain in human subjects with lingual nerve neuromas
por: Bird, Emma V, et al.
Publicado: (2013)

Influence of androgenic blockade with flutamide on pain behaviour and expression of the genes that encode the NaV1.7 and NaV1.8 voltage-dependent sodium channels in a rat model of postoperative pain
por: Barbosa Neto, José Osvaldo, et al.
Publicado: (2019)

Novel Mutations Mapping to the Fourth Sodium Channel Domain of Nav1.7 Result in Variable Clinical Manifestations of Primary Erythromelalgia
por: Cregg, Roman, et al.
Publicado: (2013)

Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin
por: Wu, X, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_5pfu07i8krv02s5uhg5avuucmb