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Nitrofurantoin-induced radiation recall dermatitis

Radiation recall dermatitis (RRD) is an inflammatory skin reaction that develops in a previously quiescent radiation field triggered most commonly by chemotherapy, particularly anthracyclines and taxanes. Radiation-recall dermatitis secondary to antibiotic therapy is quite rare. The patient is 61-ye...

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Autores principales: Garrahy, Ian, Forman, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586123/
https://www.ncbi.nlm.nih.gov/pubmed/31258875
http://dx.doi.org/10.1080/20009666.2019.1623627
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author Garrahy, Ian
Forman, Daniel
author_facet Garrahy, Ian
Forman, Daniel
author_sort Garrahy, Ian
collection PubMed
description Radiation recall dermatitis (RRD) is an inflammatory skin reaction that develops in a previously quiescent radiation field triggered most commonly by chemotherapy, particularly anthracyclines and taxanes. Radiation-recall dermatitis secondary to antibiotic therapy is quite rare. The patient is 61-year-old female with a history of squamous cell carcinoma of the left breast treated with neoadjuvant carboplatin, paclitaxel, and anthracycline chemotherapy followed by surgery and subsequent whole breast radiation 6040 cGy. Eight years after completion of her radiation she developed diffuse redness of the left breast after two doses of nitrofurantoin taken for a urinary tract infection. On examination, vital signs were stable and she had an erythematous and excoriated rash on her left breast that clinically appeared to be cellulitis. Given her clinical history, coupled with the temporal relationship of starting an antibiotic, strong consideration was given for antibiotic-induced RRD. Nitrofurantoin was discontinued, and the rash resolved completely within several days. This case demonstrates an example of RRD which is the development of an acute inflammatory skin reaction of a previously irradiated area most commonly triggered by chemotherapeutic agents. This case highlights antimicrobial therapy as a rare cause of RRD and underscores the importance of considering RRD in a patient presenting with an acute rash over a previously irradiated area while on antimicrobial therapy.
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spelling pubmed-65861232019-06-28 Nitrofurantoin-induced radiation recall dermatitis Garrahy, Ian Forman, Daniel J Community Hosp Intern Med Perspect Case Report Radiation recall dermatitis (RRD) is an inflammatory skin reaction that develops in a previously quiescent radiation field triggered most commonly by chemotherapy, particularly anthracyclines and taxanes. Radiation-recall dermatitis secondary to antibiotic therapy is quite rare. The patient is 61-year-old female with a history of squamous cell carcinoma of the left breast treated with neoadjuvant carboplatin, paclitaxel, and anthracycline chemotherapy followed by surgery and subsequent whole breast radiation 6040 cGy. Eight years after completion of her radiation she developed diffuse redness of the left breast after two doses of nitrofurantoin taken for a urinary tract infection. On examination, vital signs were stable and she had an erythematous and excoriated rash on her left breast that clinically appeared to be cellulitis. Given her clinical history, coupled with the temporal relationship of starting an antibiotic, strong consideration was given for antibiotic-induced RRD. Nitrofurantoin was discontinued, and the rash resolved completely within several days. This case demonstrates an example of RRD which is the development of an acute inflammatory skin reaction of a previously irradiated area most commonly triggered by chemotherapeutic agents. This case highlights antimicrobial therapy as a rare cause of RRD and underscores the importance of considering RRD in a patient presenting with an acute rash over a previously irradiated area while on antimicrobial therapy. Taylor & Francis 2019-06-19 /pmc/articles/PMC6586123/ /pubmed/31258875 http://dx.doi.org/10.1080/20009666.2019.1623627 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Greater Baltimore Medical Center. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Garrahy, Ian
Forman, Daniel
Nitrofurantoin-induced radiation recall dermatitis
title Nitrofurantoin-induced radiation recall dermatitis
title_full Nitrofurantoin-induced radiation recall dermatitis
title_fullStr Nitrofurantoin-induced radiation recall dermatitis
title_full_unstemmed Nitrofurantoin-induced radiation recall dermatitis
title_short Nitrofurantoin-induced radiation recall dermatitis
title_sort nitrofurantoin-induced radiation recall dermatitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586123/
https://www.ncbi.nlm.nih.gov/pubmed/31258875
http://dx.doi.org/10.1080/20009666.2019.1623627
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