Cargando…

Impacts of unfavourable lifestyle factors on biomarkers of liver function, inflammation and lipid status

BACKGROUND: Adopting a healthy lifestyle is associated with prolonged life expectancy. The main modifiable lifestyle-related risk factors are hazardous alcohol drinking, smoking, excess body weight and lack of physical activity. Our aim was to estimate the impact of unfavourable lifestyle factors on...

Descripción completa

Detalles Bibliográficos
Autores principales: Nivukoski, Ulla, Niemelä, Markus, Bloigu, Aini, Bloigu, Risto, Aalto, Mauri, Laatikainen, Tiina, Niemelä, Onni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586311/
https://www.ncbi.nlm.nih.gov/pubmed/31220128
http://dx.doi.org/10.1371/journal.pone.0218463
_version_ 1783428872871608320
author Nivukoski, Ulla
Niemelä, Markus
Bloigu, Aini
Bloigu, Risto
Aalto, Mauri
Laatikainen, Tiina
Niemelä, Onni
author_facet Nivukoski, Ulla
Niemelä, Markus
Bloigu, Aini
Bloigu, Risto
Aalto, Mauri
Laatikainen, Tiina
Niemelä, Onni
author_sort Nivukoski, Ulla
collection PubMed
description BACKGROUND: Adopting a healthy lifestyle is associated with prolonged life expectancy. The main modifiable lifestyle-related risk factors are hazardous alcohol drinking, smoking, excess body weight and lack of physical activity. Our aim was to estimate the impact of unfavourable lifestyle factors on abnormalities in laboratory tests reflecting liver status, inflammation and lipid metabolism in a population-based cross-sectional study. METHODS: The study included 22,273 participants (10,561 men, 11,712 women) aged 25–74 years from the National FINRISK Study. Data on alcohol use, smoking, body weight, and physical activity were recorded from structured interviews. The risk scores for the various life style factors were established on a 0–8 scale and used to stratify the population in classes to allow estimates of their joint effects. Serum liver enzymes (GGT, ALT), C-reactive protein (CRP) and lipid profiles were measured using standard laboratory techniques. RESULTS: Consistent dose-response relationships were observed between the number of unfavourable risk factors and serum levels of GGT, ALT, CRP, cholesterol, HDL, LDL and triglycerides (p < 0.0005 for linear trend in all comparisons). When compared with those with zero risk factors, the multivariable-adjusted odds ratios (ORs) for abnormalities in all biomarkers were significantly higher in those with a sum of risk score two or more. The most striking increases in ORs in the group with the highest numbers of risk factors were observed among men in serum GGT: 26.6 (12.4–57.0), ALT: 40.3 (5.3–307.8), CRP: 16.2 (7.8–33.7) and serum triglycerides: 14.4 (8.6–24.0). CONCLUSIONS: The data support the view that the presence of unfavourable life style risk factors is associated with distinct abnormalities in laboratory tests for liver function, inflammation and lipid status. Such biomarkers may prove to be of value in the assessment of interventions aimed at reducing unfavourable risk factors and in helping individuals in long-term maintenance of lifestyle modifications.
format Online
Article
Text
id pubmed-6586311
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-65863112019-06-28 Impacts of unfavourable lifestyle factors on biomarkers of liver function, inflammation and lipid status Nivukoski, Ulla Niemelä, Markus Bloigu, Aini Bloigu, Risto Aalto, Mauri Laatikainen, Tiina Niemelä, Onni PLoS One Research Article BACKGROUND: Adopting a healthy lifestyle is associated with prolonged life expectancy. The main modifiable lifestyle-related risk factors are hazardous alcohol drinking, smoking, excess body weight and lack of physical activity. Our aim was to estimate the impact of unfavourable lifestyle factors on abnormalities in laboratory tests reflecting liver status, inflammation and lipid metabolism in a population-based cross-sectional study. METHODS: The study included 22,273 participants (10,561 men, 11,712 women) aged 25–74 years from the National FINRISK Study. Data on alcohol use, smoking, body weight, and physical activity were recorded from structured interviews. The risk scores for the various life style factors were established on a 0–8 scale and used to stratify the population in classes to allow estimates of their joint effects. Serum liver enzymes (GGT, ALT), C-reactive protein (CRP) and lipid profiles were measured using standard laboratory techniques. RESULTS: Consistent dose-response relationships were observed between the number of unfavourable risk factors and serum levels of GGT, ALT, CRP, cholesterol, HDL, LDL and triglycerides (p < 0.0005 for linear trend in all comparisons). When compared with those with zero risk factors, the multivariable-adjusted odds ratios (ORs) for abnormalities in all biomarkers were significantly higher in those with a sum of risk score two or more. The most striking increases in ORs in the group with the highest numbers of risk factors were observed among men in serum GGT: 26.6 (12.4–57.0), ALT: 40.3 (5.3–307.8), CRP: 16.2 (7.8–33.7) and serum triglycerides: 14.4 (8.6–24.0). CONCLUSIONS: The data support the view that the presence of unfavourable life style risk factors is associated with distinct abnormalities in laboratory tests for liver function, inflammation and lipid status. Such biomarkers may prove to be of value in the assessment of interventions aimed at reducing unfavourable risk factors and in helping individuals in long-term maintenance of lifestyle modifications. Public Library of Science 2019-06-20 /pmc/articles/PMC6586311/ /pubmed/31220128 http://dx.doi.org/10.1371/journal.pone.0218463 Text en © 2019 Nivukoski et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nivukoski, Ulla
Niemelä, Markus
Bloigu, Aini
Bloigu, Risto
Aalto, Mauri
Laatikainen, Tiina
Niemelä, Onni
Impacts of unfavourable lifestyle factors on biomarkers of liver function, inflammation and lipid status
title Impacts of unfavourable lifestyle factors on biomarkers of liver function, inflammation and lipid status
title_full Impacts of unfavourable lifestyle factors on biomarkers of liver function, inflammation and lipid status
title_fullStr Impacts of unfavourable lifestyle factors on biomarkers of liver function, inflammation and lipid status
title_full_unstemmed Impacts of unfavourable lifestyle factors on biomarkers of liver function, inflammation and lipid status
title_short Impacts of unfavourable lifestyle factors on biomarkers of liver function, inflammation and lipid status
title_sort impacts of unfavourable lifestyle factors on biomarkers of liver function, inflammation and lipid status
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586311/
https://www.ncbi.nlm.nih.gov/pubmed/31220128
http://dx.doi.org/10.1371/journal.pone.0218463
work_keys_str_mv AT nivukoskiulla impactsofunfavourablelifestylefactorsonbiomarkersofliverfunctioninflammationandlipidstatus
AT niemelamarkus impactsofunfavourablelifestylefactorsonbiomarkersofliverfunctioninflammationandlipidstatus
AT bloiguaini impactsofunfavourablelifestylefactorsonbiomarkersofliverfunctioninflammationandlipidstatus
AT bloiguristo impactsofunfavourablelifestylefactorsonbiomarkersofliverfunctioninflammationandlipidstatus
AT aaltomauri impactsofunfavourablelifestylefactorsonbiomarkersofliverfunctioninflammationandlipidstatus
AT laatikainentiina impactsofunfavourablelifestylefactorsonbiomarkersofliverfunctioninflammationandlipidstatus
AT niemelaonni impactsofunfavourablelifestylefactorsonbiomarkersofliverfunctioninflammationandlipidstatus