Increased type III TGF-β receptor shedding decreases tumorigenesis through induction of epithelial-to-mesenchymal transition

The type III TGF-β receptor (TβRIII) is a TGF-β co-receptor that presents ligand to the type II TGF-β receptor to initiate signaling. TβRIII also undergoes ectodomain shedding to release a soluble form (sTβRIII) that can bind ligand, sequestering it away from cell surface receptors. We have previous...

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Detalles Bibliográficos
Autores principales: Huang, Jennifer J., Corona, Armando L., Dunn, Brian P., Cai, Elise M., Prakken, Jesse N., Blobe, Gerard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586422/
https://www.ncbi.nlm.nih.gov/pubmed/30643193
http://dx.doi.org/10.1038/s41388-018-0672-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586422/
https://www.ncbi.nlm.nih.gov/pubmed/30643193
http://dx.doi.org/10.1038/s41388-018-0672-7

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