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A real‐world experience with 6 months of antitubercular therapy in abdominal tuberculosis

BACKGROUND AND AIM: Abdominal tuberculosis is an important form of extrapulmonary tuberculosis. Evidence from clinical trials suggests that 6 months of antitubercular therapy (ATT) is sufficient for abdominal tuberculosis. METHODS: We report real‐world experience with 6 months of ATT based on a retr...

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Autores principales: Mandavdhare, Harshal S, Singh, Harjeet, Dutta, Usha, Sharma, Vishal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Publishing Asia Pty Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586575/
https://www.ncbi.nlm.nih.gov/pubmed/31276036
http://dx.doi.org/10.1002/jgh3.12136
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author Mandavdhare, Harshal S
Singh, Harjeet
Dutta, Usha
Sharma, Vishal
author_facet Mandavdhare, Harshal S
Singh, Harjeet
Dutta, Usha
Sharma, Vishal
author_sort Mandavdhare, Harshal S
collection PubMed
description BACKGROUND AND AIM: Abdominal tuberculosis is an important form of extrapulmonary tuberculosis. Evidence from clinical trials suggests that 6 months of antitubercular therapy (ATT) is sufficient for abdominal tuberculosis. METHODS: We report real‐world experience with 6 months of ATT based on a retrospective analysis of patients with abdominal tuberculosis seen at a large tertiary care hospital in India. RESULTS: Of 101 patients, 93 with complete records were included. The mean age was 35.90 ± 14.06 years, and 53 were males (56.98%). A total of 42 patients (45.16%) had intestinal involvement, 24 (25.08%) had peritoneal, 22 (23.65%) had combined involvement, and 5 patients (5.37%) had isolated lymph nodal involvement. Six patients received prolonged ATT. Six patients developed ATT‐induced hepatitis. Of 64 patients with intestinal involvement, 45 had stricturing disease (70.3%), of whom 7 (15.5%) required surgery due to refractory symptoms. Overall, there was one death, and eight patients (including one with massive gastrointestinal bleeding) needed surgery. CONCLUSION: Six months of ATT is associated with objective clinical response in most of the patients of abdominal tuberculosis.
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spelling pubmed-65865752019-07-02 A real‐world experience with 6 months of antitubercular therapy in abdominal tuberculosis Mandavdhare, Harshal S Singh, Harjeet Dutta, Usha Sharma, Vishal JGH Open Original Articles BACKGROUND AND AIM: Abdominal tuberculosis is an important form of extrapulmonary tuberculosis. Evidence from clinical trials suggests that 6 months of antitubercular therapy (ATT) is sufficient for abdominal tuberculosis. METHODS: We report real‐world experience with 6 months of ATT based on a retrospective analysis of patients with abdominal tuberculosis seen at a large tertiary care hospital in India. RESULTS: Of 101 patients, 93 with complete records were included. The mean age was 35.90 ± 14.06 years, and 53 were males (56.98%). A total of 42 patients (45.16%) had intestinal involvement, 24 (25.08%) had peritoneal, 22 (23.65%) had combined involvement, and 5 patients (5.37%) had isolated lymph nodal involvement. Six patients received prolonged ATT. Six patients developed ATT‐induced hepatitis. Of 64 patients with intestinal involvement, 45 had stricturing disease (70.3%), of whom 7 (15.5%) required surgery due to refractory symptoms. Overall, there was one death, and eight patients (including one with massive gastrointestinal bleeding) needed surgery. CONCLUSION: Six months of ATT is associated with objective clinical response in most of the patients of abdominal tuberculosis. Wiley Publishing Asia Pty Ltd 2019-01-16 /pmc/articles/PMC6586575/ /pubmed/31276036 http://dx.doi.org/10.1002/jgh3.12136 Text en © 2019 The Authors. JGH Open: An open access journal of gastroenterology and hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Mandavdhare, Harshal S
Singh, Harjeet
Dutta, Usha
Sharma, Vishal
A real‐world experience with 6 months of antitubercular therapy in abdominal tuberculosis
title A real‐world experience with 6 months of antitubercular therapy in abdominal tuberculosis
title_full A real‐world experience with 6 months of antitubercular therapy in abdominal tuberculosis
title_fullStr A real‐world experience with 6 months of antitubercular therapy in abdominal tuberculosis
title_full_unstemmed A real‐world experience with 6 months of antitubercular therapy in abdominal tuberculosis
title_short A real‐world experience with 6 months of antitubercular therapy in abdominal tuberculosis
title_sort real‐world experience with 6 months of antitubercular therapy in abdominal tuberculosis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586575/
https://www.ncbi.nlm.nih.gov/pubmed/31276036
http://dx.doi.org/10.1002/jgh3.12136
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