Methylation and transcription patterns are distinct in IDH mutant gliomas compared to other IDH mutant cancers

Mutations in isocitrate dehydrogenases 1 and 2 (IDH(mut)) are present in a variety of cancers, including glioma, acute myeloid leukemia (AML), melanoma, and cholangiocarcinoma. These mutations promote hypermethylation, yet it is only a favorable prognostic marker in glioma, for reasons that are uncl...

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Detalles Bibliográficos
Autores principales: Unruh, Dusten, Zewde, Makda, Buss, Adam, Drumm, Michael R., Tran, Anh N., Scholtens, Denise M., Horbinski, Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586617/
https://www.ncbi.nlm.nih.gov/pubmed/31222125
http://dx.doi.org/10.1038/s41598-019-45346-1

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