Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation

The different stages of the metastatic cascade present distinct metabolic challenges to tumour cells and an altered tumour metabolism associated with successful metastatic colonisation provides a therapeutic vulnerability in disseminated disease. We identify the aldo-keto reductase AKR1B10 as a meta...

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Detalles Bibliográficos
Autores principales: van Weverwijk, Antoinette, Koundouros, Nikolaos, Iravani, Marjan, Ashenden, Matthew, Gao, Qiong, Poulogiannis, George, Jungwirth, Ute, Isacke, Clare M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586667/
https://www.ncbi.nlm.nih.gov/pubmed/31221959
http://dx.doi.org/10.1038/s41467-019-10592-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586667/
https://www.ncbi.nlm.nih.gov/pubmed/31221959
http://dx.doi.org/10.1038/s41467-019-10592-4

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