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A striatal interneuron circuit for continuous target pursuit

Most adaptive behaviors require precise tracking of targets in space. In pursuit behavior with a moving target, mice use distance to target to guide their own movement continuously. Here, we show that in the sensorimotor striatum, parvalbumin-positive fast-spiking interneurons (FSIs) can represent t...

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Autores principales: Kim, Namsoo, Li, Haofang E., Hughes, Ryan N., Watson, Glenn D. R., Gallegos, David, West, Anne E., Kim, Il Hwan, Yin, Henry H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586681/
https://www.ncbi.nlm.nih.gov/pubmed/31222009
http://dx.doi.org/10.1038/s41467-019-10716-w
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author Kim, Namsoo
Li, Haofang E.
Hughes, Ryan N.
Watson, Glenn D. R.
Gallegos, David
West, Anne E.
Kim, Il Hwan
Yin, Henry H.
author_facet Kim, Namsoo
Li, Haofang E.
Hughes, Ryan N.
Watson, Glenn D. R.
Gallegos, David
West, Anne E.
Kim, Il Hwan
Yin, Henry H.
author_sort Kim, Namsoo
collection PubMed
description Most adaptive behaviors require precise tracking of targets in space. In pursuit behavior with a moving target, mice use distance to target to guide their own movement continuously. Here, we show that in the sensorimotor striatum, parvalbumin-positive fast-spiking interneurons (FSIs) can represent the distance between self and target during pursuit behavior, while striatal projection neurons (SPNs), which receive FSI projections, can represent self-velocity. FSIs are shown to regulate velocity-related SPN activity during pursuit, so that movement velocity is continuously modulated by distance to target. Moreover, bidirectional manipulation of FSI activity can selectively disrupt performance by increasing or decreasing the self-target distance. Our results reveal a key role of the FSI-SPN interneuron circuit in pursuit behavior and elucidate how this circuit implements distance to velocity transformation required for the critical underlying computation.
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spelling pubmed-65866812019-06-24 A striatal interneuron circuit for continuous target pursuit Kim, Namsoo Li, Haofang E. Hughes, Ryan N. Watson, Glenn D. R. Gallegos, David West, Anne E. Kim, Il Hwan Yin, Henry H. Nat Commun Article Most adaptive behaviors require precise tracking of targets in space. In pursuit behavior with a moving target, mice use distance to target to guide their own movement continuously. Here, we show that in the sensorimotor striatum, parvalbumin-positive fast-spiking interneurons (FSIs) can represent the distance between self and target during pursuit behavior, while striatal projection neurons (SPNs), which receive FSI projections, can represent self-velocity. FSIs are shown to regulate velocity-related SPN activity during pursuit, so that movement velocity is continuously modulated by distance to target. Moreover, bidirectional manipulation of FSI activity can selectively disrupt performance by increasing or decreasing the self-target distance. Our results reveal a key role of the FSI-SPN interneuron circuit in pursuit behavior and elucidate how this circuit implements distance to velocity transformation required for the critical underlying computation. Nature Publishing Group UK 2019-06-20 /pmc/articles/PMC6586681/ /pubmed/31222009 http://dx.doi.org/10.1038/s41467-019-10716-w Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kim, Namsoo
Li, Haofang E.
Hughes, Ryan N.
Watson, Glenn D. R.
Gallegos, David
West, Anne E.
Kim, Il Hwan
Yin, Henry H.
A striatal interneuron circuit for continuous target pursuit
title A striatal interneuron circuit for continuous target pursuit
title_full A striatal interneuron circuit for continuous target pursuit
title_fullStr A striatal interneuron circuit for continuous target pursuit
title_full_unstemmed A striatal interneuron circuit for continuous target pursuit
title_short A striatal interneuron circuit for continuous target pursuit
title_sort striatal interneuron circuit for continuous target pursuit
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586681/
https://www.ncbi.nlm.nih.gov/pubmed/31222009
http://dx.doi.org/10.1038/s41467-019-10716-w
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