Screening DNA-targeted anticancer drug in vitro based on cancer cells DNA-templated silver nanoclusters

A reliable and sensitive cancer cells DNA-templated silver nanoclusters probe has been proposed for screening DNA-targeted anticancer drugs in vitro. In this paper, the DNA-templated silver nanoclusters was used to investigate the binding between anthracycline antibiotics and DNA. The template of DN...

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Detalles Bibliográficos
Autores principales: Zhang, Feng, Sheng, Hao, Wang, Shuang, Ma, Yu, Cai, Changqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586784/
https://www.ncbi.nlm.nih.gov/pubmed/31222176
http://dx.doi.org/10.1038/s41598-019-45523-2
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author Zhang, Feng
Sheng, Hao
Wang, Shuang
Ma, Yu
Cai, Changqun
author_facet Zhang, Feng
Sheng, Hao
Wang, Shuang
Ma, Yu
Cai, Changqun
author_sort Zhang, Feng
collection PubMed
description A reliable and sensitive cancer cells DNA-templated silver nanoclusters probe has been proposed for screening DNA-targeted anticancer drugs in vitro. In this paper, the DNA-templated silver nanoclusters was used to investigate the binding between anthracycline antibiotics and DNA. The template of DNA-templated silver nanoclusters was extracted from human liver carcinoma cells directly, which can express the drug activities against cancer cells more direct than the normal cells DNA. The anti-tumor activities of the four drugs were validated by MTT and apoptotic assay as Mitoxantrone > Epirubicin > Daunorubicin > Adriamycin.
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spelling pubmed-65867842019-06-27 Screening DNA-targeted anticancer drug in vitro based on cancer cells DNA-templated silver nanoclusters Zhang, Feng Sheng, Hao Wang, Shuang Ma, Yu Cai, Changqun Sci Rep Article A reliable and sensitive cancer cells DNA-templated silver nanoclusters probe has been proposed for screening DNA-targeted anticancer drugs in vitro. In this paper, the DNA-templated silver nanoclusters was used to investigate the binding between anthracycline antibiotics and DNA. The template of DNA-templated silver nanoclusters was extracted from human liver carcinoma cells directly, which can express the drug activities against cancer cells more direct than the normal cells DNA. The anti-tumor activities of the four drugs were validated by MTT and apoptotic assay as Mitoxantrone > Epirubicin > Daunorubicin > Adriamycin. Nature Publishing Group UK 2019-06-20 /pmc/articles/PMC6586784/ /pubmed/31222176 http://dx.doi.org/10.1038/s41598-019-45523-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhang, Feng
Sheng, Hao
Wang, Shuang
Ma, Yu
Cai, Changqun
Screening DNA-targeted anticancer drug in vitro based on cancer cells DNA-templated silver nanoclusters
title Screening DNA-targeted anticancer drug in vitro based on cancer cells DNA-templated silver nanoclusters
title_full Screening DNA-targeted anticancer drug in vitro based on cancer cells DNA-templated silver nanoclusters
title_fullStr Screening DNA-targeted anticancer drug in vitro based on cancer cells DNA-templated silver nanoclusters
title_full_unstemmed Screening DNA-targeted anticancer drug in vitro based on cancer cells DNA-templated silver nanoclusters
title_short Screening DNA-targeted anticancer drug in vitro based on cancer cells DNA-templated silver nanoclusters
title_sort screening dna-targeted anticancer drug in vitro based on cancer cells dna-templated silver nanoclusters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586784/
https://www.ncbi.nlm.nih.gov/pubmed/31222176
http://dx.doi.org/10.1038/s41598-019-45523-2
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