Cargando…
Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy
In response to environmental and nutrient stress, adipose tissues must establish a new homeostatic state. Here we show that cold exposure of obese mice triggers an adaptive tissue remodeling in visceral adipose tissue (VAT) that involves extracellular matrix deposition, angiogenesis, sympathetic inn...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586812/ https://www.ncbi.nlm.nih.gov/pubmed/31222070 http://dx.doi.org/10.1038/s41598-019-45354-1 |
_version_ | 1783428948602912768 |
---|---|
author | Chang, Joshua C. Durinck, Steffen Chen, Mark Z. Martinez-Martin, Nadia Zhang, Jingli A. Lehoux, Isabelle Li, Hong Lin, May Wu, Jiansheng Bainbridge, Travis W. Ernst, James A. Ramani, Sree R. Paduchuri, Sairupa Kates, Lance Solon, Margaret Buechler, Matthew B. Castiglioni, Alessandra Thai, Minh Breart, Beatrice Modrusan, Zora Peterson, Andrew S. Turley, Shannon J. Sonoda, Junichiro |
author_facet | Chang, Joshua C. Durinck, Steffen Chen, Mark Z. Martinez-Martin, Nadia Zhang, Jingli A. Lehoux, Isabelle Li, Hong Lin, May Wu, Jiansheng Bainbridge, Travis W. Ernst, James A. Ramani, Sree R. Paduchuri, Sairupa Kates, Lance Solon, Margaret Buechler, Matthew B. Castiglioni, Alessandra Thai, Minh Breart, Beatrice Modrusan, Zora Peterson, Andrew S. Turley, Shannon J. Sonoda, Junichiro |
author_sort | Chang, Joshua C. |
collection | PubMed |
description | In response to environmental and nutrient stress, adipose tissues must establish a new homeostatic state. Here we show that cold exposure of obese mice triggers an adaptive tissue remodeling in visceral adipose tissue (VAT) that involves extracellular matrix deposition, angiogenesis, sympathetic innervation, and adipose tissue browning. Obese VAT is predominated by pro-inflammatory M1 macrophages; cold exposure induces an M1-to-M2 shift in macrophage composition and dramatic changes in macrophage gene expression in both M1 and M2 macrophages. Antibody-mediated CSF1R blocking prevented the cold-induced recruitment of adipose tissue M2 macrophages, suggesting the role of CSF1R signaling in the process. These cold-induced effects in obese VAT are phenocopied by an administration of the FGF21-mimetic antibody, consistent with its action to stimulate sympathetic nerves. Collectively, these studies illuminate adaptive visceral adipose tissue plasticity in obese mice in response to cold stress and antibody-based metabolic therapy. |
format | Online Article Text |
id | pubmed-6586812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-65868122019-06-27 Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy Chang, Joshua C. Durinck, Steffen Chen, Mark Z. Martinez-Martin, Nadia Zhang, Jingli A. Lehoux, Isabelle Li, Hong Lin, May Wu, Jiansheng Bainbridge, Travis W. Ernst, James A. Ramani, Sree R. Paduchuri, Sairupa Kates, Lance Solon, Margaret Buechler, Matthew B. Castiglioni, Alessandra Thai, Minh Breart, Beatrice Modrusan, Zora Peterson, Andrew S. Turley, Shannon J. Sonoda, Junichiro Sci Rep Article In response to environmental and nutrient stress, adipose tissues must establish a new homeostatic state. Here we show that cold exposure of obese mice triggers an adaptive tissue remodeling in visceral adipose tissue (VAT) that involves extracellular matrix deposition, angiogenesis, sympathetic innervation, and adipose tissue browning. Obese VAT is predominated by pro-inflammatory M1 macrophages; cold exposure induces an M1-to-M2 shift in macrophage composition and dramatic changes in macrophage gene expression in both M1 and M2 macrophages. Antibody-mediated CSF1R blocking prevented the cold-induced recruitment of adipose tissue M2 macrophages, suggesting the role of CSF1R signaling in the process. These cold-induced effects in obese VAT are phenocopied by an administration of the FGF21-mimetic antibody, consistent with its action to stimulate sympathetic nerves. Collectively, these studies illuminate adaptive visceral adipose tissue plasticity in obese mice in response to cold stress and antibody-based metabolic therapy. Nature Publishing Group UK 2019-06-20 /pmc/articles/PMC6586812/ /pubmed/31222070 http://dx.doi.org/10.1038/s41598-019-45354-1 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Chang, Joshua C. Durinck, Steffen Chen, Mark Z. Martinez-Martin, Nadia Zhang, Jingli A. Lehoux, Isabelle Li, Hong Lin, May Wu, Jiansheng Bainbridge, Travis W. Ernst, James A. Ramani, Sree R. Paduchuri, Sairupa Kates, Lance Solon, Margaret Buechler, Matthew B. Castiglioni, Alessandra Thai, Minh Breart, Beatrice Modrusan, Zora Peterson, Andrew S. Turley, Shannon J. Sonoda, Junichiro Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy |
title | Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy |
title_full | Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy |
title_fullStr | Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy |
title_full_unstemmed | Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy |
title_short | Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy |
title_sort | adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586812/ https://www.ncbi.nlm.nih.gov/pubmed/31222070 http://dx.doi.org/10.1038/s41598-019-45354-1 |
work_keys_str_mv | AT changjoshuac adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT durincksteffen adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT chenmarkz adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT martinezmartinnadia adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT zhangjinglia adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT lehouxisabelle adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT lihong adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT linmay adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT wujiansheng adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT bainbridgetravisw adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT ernstjamesa adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT ramanisreer adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT paduchurisairupa adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT kateslance adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT solonmargaret adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT buechlermatthewb adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT castiglionialessandra adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT thaiminh adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT breartbeatrice adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT modrusanzora adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT petersonandrews adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT turleyshannonj adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy AT sonodajunichiro adaptiveadiposetissuestromalplasticityinresponsetocoldstressandantibodybasedmetabolictherapy |