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ATP binds and inhibits the neurodegeneration-associated fibrillization of the FUS RRM domain
Adenosine triphosphate (ATP) provides energy for cellular processes but has recently been found to act also as a hydrotrope to maintain protein homeostasis. ATP bivalently binds the disordered domain of FUS containing the RG/RGG sequence motif and thereby affects FUS liquid-liquid phase separation....
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586847/ https://www.ncbi.nlm.nih.gov/pubmed/31240261 http://dx.doi.org/10.1038/s42003-019-0463-x |