Cargando…

The effectiveness of N-acetylcysteine for an adult case of pulmonary alveolar proteinosis: A case report

INTRODUCTION: Pulmonary alveolar proteinosis is a rare disease that is characterized by accumulation of surfactant and phospholipids in the pulmonary alveoli. The current mainstay of treatment is whole lung lavage. There have been rare reports that have revealed the effectiveness of N-acetylcysteine...

Descripción completa

Detalles Bibliográficos
Autor principal: Zhang, Haiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586945/
https://www.ncbi.nlm.nih.gov/pubmed/31249778
http://dx.doi.org/10.1016/j.rmcr.2019.100883
_version_ 1783428978462162944
author Zhang, Haiyan
author_facet Zhang, Haiyan
author_sort Zhang, Haiyan
collection PubMed
description INTRODUCTION: Pulmonary alveolar proteinosis is a rare disease that is characterized by accumulation of surfactant and phospholipids in the pulmonary alveoli. The current mainstay of treatment is whole lung lavage. There have been rare reports that have revealed the effectiveness of N-acetylcysteine on a secondary PAP. CASE PRESENTATION: A 45-year old man complained of shortness of breath and a productive cough with white sputum. He inhaled stone powder as an occupational hazard. CT scan of his chest radiograph showed ground glass changes superimposed on a reticular pattern as the so-called ‘crazy paving’ pattern. Lung biopsy revealed alveolar proteinaceous material with positive PAS stain. He eventually was diagnosed as PAP. He refused a whole lung lavage therapy, so the patient was rendered N-acetylcysteine as an antioxidant, enhanced immunotherapy and anti-infective treatment. His clinical symptoms and radiological manifestation improved gradually. No substantial adverse reactions were reported. CONCLUSIONS: Persistent oral N-acetylcysteine may be an alternative treatment option for secondary PAP.
format Online
Article
Text
id pubmed-6586945
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-65869452019-06-27 The effectiveness of N-acetylcysteine for an adult case of pulmonary alveolar proteinosis: A case report Zhang, Haiyan Respir Med Case Rep Case Report INTRODUCTION: Pulmonary alveolar proteinosis is a rare disease that is characterized by accumulation of surfactant and phospholipids in the pulmonary alveoli. The current mainstay of treatment is whole lung lavage. There have been rare reports that have revealed the effectiveness of N-acetylcysteine on a secondary PAP. CASE PRESENTATION: A 45-year old man complained of shortness of breath and a productive cough with white sputum. He inhaled stone powder as an occupational hazard. CT scan of his chest radiograph showed ground glass changes superimposed on a reticular pattern as the so-called ‘crazy paving’ pattern. Lung biopsy revealed alveolar proteinaceous material with positive PAS stain. He eventually was diagnosed as PAP. He refused a whole lung lavage therapy, so the patient was rendered N-acetylcysteine as an antioxidant, enhanced immunotherapy and anti-infective treatment. His clinical symptoms and radiological manifestation improved gradually. No substantial adverse reactions were reported. CONCLUSIONS: Persistent oral N-acetylcysteine may be an alternative treatment option for secondary PAP. Elsevier 2019-06-14 /pmc/articles/PMC6586945/ /pubmed/31249778 http://dx.doi.org/10.1016/j.rmcr.2019.100883 Text en © 2019 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Zhang, Haiyan
The effectiveness of N-acetylcysteine for an adult case of pulmonary alveolar proteinosis: A case report
title The effectiveness of N-acetylcysteine for an adult case of pulmonary alveolar proteinosis: A case report
title_full The effectiveness of N-acetylcysteine for an adult case of pulmonary alveolar proteinosis: A case report
title_fullStr The effectiveness of N-acetylcysteine for an adult case of pulmonary alveolar proteinosis: A case report
title_full_unstemmed The effectiveness of N-acetylcysteine for an adult case of pulmonary alveolar proteinosis: A case report
title_short The effectiveness of N-acetylcysteine for an adult case of pulmonary alveolar proteinosis: A case report
title_sort effectiveness of n-acetylcysteine for an adult case of pulmonary alveolar proteinosis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586945/
https://www.ncbi.nlm.nih.gov/pubmed/31249778
http://dx.doi.org/10.1016/j.rmcr.2019.100883
work_keys_str_mv AT zhanghaiyan theeffectivenessofnacetylcysteineforanadultcaseofpulmonaryalveolarproteinosisacasereport
AT zhanghaiyan effectivenessofnacetylcysteineforanadultcaseofpulmonaryalveolarproteinosisacasereport