Single pembrolizumab treatment causing profound durable response in a patient with pulmonary pleomorphic carcinoma

We report a case of a 73-year-old man diagnosed with pulmonary pleomorphic carcinoma who showed profound durable response after a single treatment with pembrolizumab. The patient underwent a diagnostic workup in our hospital due to a hoarseness of voice. Chest computed tomography revealed a massive...

Descripción completa

Detalles Bibliográficos
Autores principales: Tokuyasu, Hirokazu, Ishikawa, Soichiro, Sakai, Hiromitsu, Ikeuchi, Tomoyuki, Miura, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586952/
https://www.ncbi.nlm.nih.gov/pubmed/31249776
http://dx.doi.org/10.1016/j.rmcr.2019.100879
_version_ 1783428980084310016
author Tokuyasu, Hirokazu
Ishikawa, Soichiro
Sakai, Hiromitsu
Ikeuchi, Tomoyuki
Miura, Hiroshi
author_facet Tokuyasu, Hirokazu
Ishikawa, Soichiro
Sakai, Hiromitsu
Ikeuchi, Tomoyuki
Miura, Hiroshi
author_sort Tokuyasu, Hirokazu
collection PubMed
description We report a case of a 73-year-old man diagnosed with pulmonary pleomorphic carcinoma who showed profound durable response after a single treatment with pembrolizumab. The patient underwent a diagnostic workup in our hospital due to a hoarseness of voice. Chest computed tomography revealed a massive pulmonary tumor in the left upper lobe and multiple nodules in the both lung fields. Histological examination of a transbronchial lung biopsy specimen revealed pulmonary pleomorphic carcinoma. First-line treatment with pembrolizumab was discontinued after a single administration due to treatment-related pneumonitis. However, durable response has been observed over 17 months to date.
format Online
Article
Text
id pubmed-6586952
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-65869522019-06-27 Single pembrolizumab treatment causing profound durable response in a patient with pulmonary pleomorphic carcinoma Tokuyasu, Hirokazu Ishikawa, Soichiro Sakai, Hiromitsu Ikeuchi, Tomoyuki Miura, Hiroshi Respir Med Case Rep Case Report We report a case of a 73-year-old man diagnosed with pulmonary pleomorphic carcinoma who showed profound durable response after a single treatment with pembrolizumab. The patient underwent a diagnostic workup in our hospital due to a hoarseness of voice. Chest computed tomography revealed a massive pulmonary tumor in the left upper lobe and multiple nodules in the both lung fields. Histological examination of a transbronchial lung biopsy specimen revealed pulmonary pleomorphic carcinoma. First-line treatment with pembrolizumab was discontinued after a single administration due to treatment-related pneumonitis. However, durable response has been observed over 17 months to date. Elsevier 2019-06-11 /pmc/articles/PMC6586952/ /pubmed/31249776 http://dx.doi.org/10.1016/j.rmcr.2019.100879 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tokuyasu, Hirokazu
Ishikawa, Soichiro
Sakai, Hiromitsu
Ikeuchi, Tomoyuki
Miura, Hiroshi
Single pembrolizumab treatment causing profound durable response in a patient with pulmonary pleomorphic carcinoma
title Single pembrolizumab treatment causing profound durable response in a patient with pulmonary pleomorphic carcinoma
title_full Single pembrolizumab treatment causing profound durable response in a patient with pulmonary pleomorphic carcinoma
title_fullStr Single pembrolizumab treatment causing profound durable response in a patient with pulmonary pleomorphic carcinoma
title_full_unstemmed Single pembrolizumab treatment causing profound durable response in a patient with pulmonary pleomorphic carcinoma
title_short Single pembrolizumab treatment causing profound durable response in a patient with pulmonary pleomorphic carcinoma
title_sort single pembrolizumab treatment causing profound durable response in a patient with pulmonary pleomorphic carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586952/
https://www.ncbi.nlm.nih.gov/pubmed/31249776
http://dx.doi.org/10.1016/j.rmcr.2019.100879
work_keys_str_mv AT tokuyasuhirokazu singlepembrolizumabtreatmentcausingprofounddurableresponseinapatientwithpulmonarypleomorphiccarcinoma
AT ishikawasoichiro singlepembrolizumabtreatmentcausingprofounddurableresponseinapatientwithpulmonarypleomorphiccarcinoma
AT sakaihiromitsu singlepembrolizumabtreatmentcausingprofounddurableresponseinapatientwithpulmonarypleomorphiccarcinoma
AT ikeuchitomoyuki singlepembrolizumabtreatmentcausingprofounddurableresponseinapatientwithpulmonarypleomorphiccarcinoma
AT miurahiroshi singlepembrolizumabtreatmentcausingprofounddurableresponseinapatientwithpulmonarypleomorphiccarcinoma

Ejemplares similares