Imaging biomarkers in oncology: Basics and application to MRI

Cancer remains a global killer alongside cardiovascular disease. A better understanding of cancer biology has transformed its management with an increasing emphasis on a personalized approach, so‐called “precision cancer medicine.” Imaging has a key role to play in the management of cancer patients....

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Detalles Bibliográficos
Autores principales: Dregely, Isabel, Prezzi, Davide, Kelly‐Morland, Christian, Roccia, Elisa, Neji, Radhouene, Goh, Vicky
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
CME Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587121/
https://www.ncbi.nlm.nih.gov/pubmed/29969192
http://dx.doi.org/10.1002/jmri.26058
Descripción
Sumario:Cancer remains a global killer alongside cardiovascular disease. A better understanding of cancer biology has transformed its management with an increasing emphasis on a personalized approach, so‐called “precision cancer medicine.” Imaging has a key role to play in the management of cancer patients. Imaging biomarkers that objectively inform on tumor biology, the tumor environment, and tumor changes in response to an intervention complement genomic and molecular diagnostics. In this review we describe the key principles for imaging biomarker development and discuss the current status with respect to magnetic resonance imaging (MRI). LEVEL OF EVIDENCE: 5 TECHNICAL EFFICACY: Stage 5 J. Magn. Reson. Imaging 2018;48:13–26.

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