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Factors Associated with Low Admission Platelet Count in Adults with Acute Aortic Dissection

Purpose: Platelets are crucial components of the coagulation processes, and low admission platelet count (PLC) is associated with adverse clinical outcomes in patients with Stanford type A acute aortic dissection (AAD). Methods: A total of 130 consecutive patients undergoing Stanford type A AAD surg...

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Autores principales: Li, Shuwen, Lu, Jiakai, Cheng, Weiping, Zhu, Junming, Jin, Mu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587131/
https://www.ncbi.nlm.nih.gov/pubmed/30568075
http://dx.doi.org/10.5761/atcs.oa.18-00187
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author Li, Shuwen
Lu, Jiakai
Cheng, Weiping
Zhu, Junming
Jin, Mu
author_facet Li, Shuwen
Lu, Jiakai
Cheng, Weiping
Zhu, Junming
Jin, Mu
author_sort Li, Shuwen
collection PubMed
description Purpose: Platelets are crucial components of the coagulation processes, and low admission platelet count (PLC) is associated with adverse clinical outcomes in patients with Stanford type A acute aortic dissection (AAD). Methods: A total of 130 consecutive patients undergoing Stanford type A AAD surgery in Beijing Anzhen Hospital were enrolled between January 2013 and July 2014. Preoperative clinical and laboratory data from patients were collected. Multiple regression analyses were used to determine the independent factors of low admission platelets. Results: Adjusted multiple regression analysis showed that age (β: −1.069, 95% confidence interval [CI]: −2.109, −0.029), sex (β: −29.973, 95% CI: −56.512, −3.433), tissue factor pathway inhibitor (TFPI; β: 0.197, 95% CI: 0.039, 0.354), fibrinogen degradation product (FDP) (β: −0.476, 95% CI: −0.879, −0.074), and attack time (β: 11.125, 95% CI: 7.963, 14.287) were significantly associated with admission PLC. Admission PLC increased with attack time up to the 3 days (β: 16.2, 95% CI: 12.1, 20.2). Conclusions: We found that increasing age, male patients, patients with lower serum levels of TFPI and higher serum levels of FDP, and patients with a shorter attack time were significantly associated with lower PLC at admission. Moreover, the turning point of attack time is 3 days after the onset of dissection.
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spelling pubmed-65871312019-06-28 Factors Associated with Low Admission Platelet Count in Adults with Acute Aortic Dissection Li, Shuwen Lu, Jiakai Cheng, Weiping Zhu, Junming Jin, Mu Ann Thorac Cardiovasc Surg Original Article Purpose: Platelets are crucial components of the coagulation processes, and low admission platelet count (PLC) is associated with adverse clinical outcomes in patients with Stanford type A acute aortic dissection (AAD). Methods: A total of 130 consecutive patients undergoing Stanford type A AAD surgery in Beijing Anzhen Hospital were enrolled between January 2013 and July 2014. Preoperative clinical and laboratory data from patients were collected. Multiple regression analyses were used to determine the independent factors of low admission platelets. Results: Adjusted multiple regression analysis showed that age (β: −1.069, 95% confidence interval [CI]: −2.109, −0.029), sex (β: −29.973, 95% CI: −56.512, −3.433), tissue factor pathway inhibitor (TFPI; β: 0.197, 95% CI: 0.039, 0.354), fibrinogen degradation product (FDP) (β: −0.476, 95% CI: −0.879, −0.074), and attack time (β: 11.125, 95% CI: 7.963, 14.287) were significantly associated with admission PLC. Admission PLC increased with attack time up to the 3 days (β: 16.2, 95% CI: 12.1, 20.2). Conclusions: We found that increasing age, male patients, patients with lower serum levels of TFPI and higher serum levels of FDP, and patients with a shorter attack time were significantly associated with lower PLC at admission. Moreover, the turning point of attack time is 3 days after the onset of dissection. The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery 2018-12-18 2019 /pmc/articles/PMC6587131/ /pubmed/30568075 http://dx.doi.org/10.5761/atcs.oa.18-00187 Text en ©2019 Annals of Thoracic and Cardiovascular Surgery http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives International License (http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Article
Li, Shuwen
Lu, Jiakai
Cheng, Weiping
Zhu, Junming
Jin, Mu
Factors Associated with Low Admission Platelet Count in Adults with Acute Aortic Dissection
title Factors Associated with Low Admission Platelet Count in Adults with Acute Aortic Dissection
title_full Factors Associated with Low Admission Platelet Count in Adults with Acute Aortic Dissection
title_fullStr Factors Associated with Low Admission Platelet Count in Adults with Acute Aortic Dissection
title_full_unstemmed Factors Associated with Low Admission Platelet Count in Adults with Acute Aortic Dissection
title_short Factors Associated with Low Admission Platelet Count in Adults with Acute Aortic Dissection
title_sort factors associated with low admission platelet count in adults with acute aortic dissection
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587131/
https://www.ncbi.nlm.nih.gov/pubmed/30568075
http://dx.doi.org/10.5761/atcs.oa.18-00187
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