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A population pharmacokinetic study of benzathine benzylpenicillin G administration in children and adolescents with rheumatic heart disease: new insights for improved secondary prophylaxis strategies

BACKGROUND: Benzathine benzylpenicillin G (BPG) is recommended as secondary prophylaxis to prevent recurrence of acute rheumatic fever and subsequent rheumatic heart disease (RHD). Following intramuscular injection, BPG is hydrolysed to benzylpenicillin. Little is known of the pharmacokinetics of be...

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Detalles Bibliográficos
Autores principales:	Hand, Robert M, Salman, Sam, Newall, Nelly, Vine, Julie, Page-Sharp, Madhu, Bowen, Asha C, Gray, Katherine, Baker, Amy, Kado, Joseph, Joseph, John, Marsh, Julie, Ramsay, James, Sika-Paotonu, Dianne, Batty, Kevin T, Manning, Laurens, Carapetis, Jonathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587412/ https://www.ncbi.nlm.nih.gov/pubmed/30989171 http://dx.doi.org/10.1093/jac/dkz076

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