M281, an Anti‐FcRn Antibody: Pharmacodynamics, Pharmacokinetics, and Safety Across the Full Range of IgG Reduction in a First‐in‐Human Study

M281 is a fully human, anti‐neonatal Fc receptor (FcRn) antibody that inhibits FcRn‐mediated immunoglobulin G (IgG) recycling to decrease pathogenic IgG while preserving IgG production. A randomized, double‐blind, placebo‐controlled, first‐in‐human study with 50 normal healthy volunteers was designe...

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Detalles Bibliográficos
Autores principales: Ling, Leona E., Hillson, Jan L., Tiessen, Renger G., Bosje, Tjerk, van Iersel, Mattheus Paulus, Nix, Darrell J., Markowitz, Lynn, Cilfone, Nicholas A., Duffner, Jay, Streisand, James B., Manning, Anthony M., Arroyo, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587432/
https://www.ncbi.nlm.nih.gov/pubmed/30402880
http://dx.doi.org/10.1002/cpt.1276

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