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Short half‐life of HPV16 E6 and E7 mRNAs sensitizes HPV16‐positive tonsillar cancer cell line HN26 to DNA‐damaging drugs

Here we show that treatment of the HPV16‐positive tonsillar cancer cell line HN26 with DNA alkylating cancer drug melphalan‐induced p53 and activated apoptosis. Melphalan reduced the levels of RNA polymerase II and cellular transcription factor Sp1 that were associated with HPV16 DNA. The resulting...

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Detalles Bibliográficos
Autores principales:	Wu, Chengjun, Nilsson, Kersti, Zheng, Yunji, Ekenstierna, Camilla, Sugiyama, Natsuki, Forslund, Ola, Kajitani, Naoko, Yu, Haoran, Wennerberg, Johan, Ekblad, Lars, Schwartz, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2018
Materias:	Infectious Causes of Cancer
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587446/ https://www.ncbi.nlm.nih.gov/pubmed/30303514 http://dx.doi.org/10.1002/ijc.31918

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