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Safety of catheter‐based radiofrequency renal denervation on branch renal arteries in a porcine model

OBJECTIVES: We aimed to investigate the safety of radiofrequency (RF)‐renal denervation (RDN) on branch renal arteries (RAs) in a porcine model. BACKGROUND: The efficacy of RF‐RDN was enhanced by treatment of the branch RA, in addition to the main RA. However, there are concerns regarding the safety...

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Autores principales: Sakaoka, Atsushi, Rousselle, Serge D., Hagiwara, Hitomi, Tellez, Armando, Hubbard, Brad, Sakakura, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587466/
https://www.ncbi.nlm.nih.gov/pubmed/30407718
http://dx.doi.org/10.1002/ccd.27953
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author Sakaoka, Atsushi
Rousselle, Serge D.
Hagiwara, Hitomi
Tellez, Armando
Hubbard, Brad
Sakakura, Kenichi
author_facet Sakaoka, Atsushi
Rousselle, Serge D.
Hagiwara, Hitomi
Tellez, Armando
Hubbard, Brad
Sakakura, Kenichi
author_sort Sakaoka, Atsushi
collection PubMed
description OBJECTIVES: We aimed to investigate the safety of radiofrequency (RF)‐renal denervation (RDN) on branch renal arteries (RAs) in a porcine model. BACKGROUND: The efficacy of RF‐RDN was enhanced by treatment of the branch RA, in addition to the main RA. However, there are concerns regarding the safety of RF‐RDN on branch RA because of their smaller diameter and proximity to the kidney. METHODS: RF was delivered to 24 RA from 12 swine. A total of 8 RA from 4 swine were untreated. Treated RA were examined by angiography and histopathology at 7, 30, and 90 days. Serum creatinine concentration, biophysical parameters during RF delivery, and renal norepinephrine concentration were also assessed. RESULTS: Angiography revealed minimal late lumen loss and diameter stenosis in the main and branch RA at any time point. There was no change in serum creatinine after RF‐RDN. Histopathologically, no augmentation of medial damage or neointimal formation was found in branch RA compared with main RA. No or minimal damage to surrounding tissues including the kidneys, ureters, lymph nodes, and muscles was observed at any time point in both the main and branch RA. Equivalent electrode temperature in the main and branch RA was achieved by automatic adjustment of output power by the generator. The renal norepinephrine concentration was significantly lower in the treated group compared with the untreated group. CONCLUSIONS: RF‐RDN on branch RA was safe in a porcine model, with stenosis‐free healing of treated arteries and negligible kidney damage at 7, 30, and 90 days.
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spelling pubmed-65874662019-07-02 Safety of catheter‐based radiofrequency renal denervation on branch renal arteries in a porcine model Sakaoka, Atsushi Rousselle, Serge D. Hagiwara, Hitomi Tellez, Armando Hubbard, Brad Sakakura, Kenichi Catheter Cardiovasc Interv PERIPHERAL VASCULAR DISEASE OBJECTIVES: We aimed to investigate the safety of radiofrequency (RF)‐renal denervation (RDN) on branch renal arteries (RAs) in a porcine model. BACKGROUND: The efficacy of RF‐RDN was enhanced by treatment of the branch RA, in addition to the main RA. However, there are concerns regarding the safety of RF‐RDN on branch RA because of their smaller diameter and proximity to the kidney. METHODS: RF was delivered to 24 RA from 12 swine. A total of 8 RA from 4 swine were untreated. Treated RA were examined by angiography and histopathology at 7, 30, and 90 days. Serum creatinine concentration, biophysical parameters during RF delivery, and renal norepinephrine concentration were also assessed. RESULTS: Angiography revealed minimal late lumen loss and diameter stenosis in the main and branch RA at any time point. There was no change in serum creatinine after RF‐RDN. Histopathologically, no augmentation of medial damage or neointimal formation was found in branch RA compared with main RA. No or minimal damage to surrounding tissues including the kidneys, ureters, lymph nodes, and muscles was observed at any time point in both the main and branch RA. Equivalent electrode temperature in the main and branch RA was achieved by automatic adjustment of output power by the generator. The renal norepinephrine concentration was significantly lower in the treated group compared with the untreated group. CONCLUSIONS: RF‐RDN on branch RA was safe in a porcine model, with stenosis‐free healing of treated arteries and negligible kidney damage at 7, 30, and 90 days. John Wiley & Sons, Inc. 2018-11-08 2019-02-15 /pmc/articles/PMC6587466/ /pubmed/30407718 http://dx.doi.org/10.1002/ccd.27953 Text en © 2018 The Authors. Catheterization and Cardiovascular Interventions published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle PERIPHERAL VASCULAR DISEASE
Sakaoka, Atsushi
Rousselle, Serge D.
Hagiwara, Hitomi
Tellez, Armando
Hubbard, Brad
Sakakura, Kenichi
Safety of catheter‐based radiofrequency renal denervation on branch renal arteries in a porcine model
title Safety of catheter‐based radiofrequency renal denervation on branch renal arteries in a porcine model
title_full Safety of catheter‐based radiofrequency renal denervation on branch renal arteries in a porcine model
title_fullStr Safety of catheter‐based radiofrequency renal denervation on branch renal arteries in a porcine model
title_full_unstemmed Safety of catheter‐based radiofrequency renal denervation on branch renal arteries in a porcine model
title_short Safety of catheter‐based radiofrequency renal denervation on branch renal arteries in a porcine model
title_sort safety of catheter‐based radiofrequency renal denervation on branch renal arteries in a porcine model
topic PERIPHERAL VASCULAR DISEASE
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587466/
https://www.ncbi.nlm.nih.gov/pubmed/30407718
http://dx.doi.org/10.1002/ccd.27953
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