Activation of WNT/β‐catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations

PIK3CA is a frequently mutated gene in cancer, including about ~15 to 20% of colorectal cancers (CRC). PIK3CA mutations lead to activation of the PI3K/AKT/mTOR signaling pathway, which plays pivotal roles in tumorigenesis. Here, we investigated the mechanism of resistance of PIK3CA‐mutant CRC cell l...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Ye‐Lim, Kim, Hwang‐Phill, Cho, Young‐Won, Min, Dong‐Wook, Cheon, Seul‐Ki, Lim, Yoo Joo, Song, Sang‐Hyun, Kim, Sung Jin, Han, Sae‐Won, Park, Kyu Joo, Kim, Tae‐You
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Cancer Therapy and Prevention
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587482/
https://www.ncbi.nlm.nih.gov/pubmed/29978469
http://dx.doi.org/10.1002/ijc.31662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587482/
https://www.ncbi.nlm.nih.gov/pubmed/29978469
http://dx.doi.org/10.1002/ijc.31662

Ejemplares similares